I am a diabetic and use to take Elavil yrs. ago and it worked well for my depression. Now I have to watch what I take because the potential to raise or lower my glucose levels. I have tried just about every anti-depressant out there thru the yrs. and Elavil (amitryptline) has been the best for me. If there is a better drug that won't affect my diabetes PLEASE let me know! I am on insulin.