Finished first week of 10 mg Viibryd. I have gained two pounds, and am needing to lose weight. Viibryd is not supposed to cause weight gain, and was wondering if anyone else has experienced this. So far, my depression is much better. Any comments are appreciated!
Has anyone experienced weight gain on Viibryd?
Question posted by loridiane on 17 Sep 2011
Last updated on 26 November 2020 by sabrli
The information on this page reflects personal experiences shared by our community members. It is not reviewed for medical accuracy and should not replace professional medical advice.
51 Answers
Finding the correct antidepressant is almost like finding a needle in a haystack. Viibryd is the only antidepressant I have ever taken that I haven’t had any side effects with. My dr helped choose this medication specifically since it’s rare to gain weight on it. I take it with deplin bc I have that genetic mutation that doesn’t carry the serotonin over to the right place correctly so this helps. Methyl folate. Wellbutrin definitely won’t make you gain if you have ever tried that but it can have other unfortunate side effects. I hope you have found what works for you! Best of luck!
I am also glad I found this response. Drug trials have surprisingly few patients in them and each body reacts differently to medications so I feel like reported side effects from drug manufacturers are limited by the few members of drug trials and the amount of reports from patients that have to be accumulated over years before manufacturers will even consider updating the medication information is insane.
I started Viibryd in April 2020. I've been morbidly obese my entire life and had gastric bypass surgery five years and lost 180 lbs. Since April I've gained 55 lbs in 4 months!!! I've had intense cravings for sugar and carbs which is completely not normal for me since bypass I've cut out unhealthy carbs and stick to fruit and whole grains in limited amounts. Even before gastric bypass surgery I was never a binge eater and never had any particular craving for sweets.
Now, if it's available to me I can find myself mindlessly eating handfuls of candies or cookies or things like that which again is absolutely not normal- and honestly I'm not even hungry when I'm doing it. the diarrhea side effect is definitely something I experienced and for a couple of hours each morning it's almost debilitating but I've been able to work my schedule around that, the weight gain however I don't know that I can deal with this.
My problem is that I have suffered from MDD since I was very young. I've been hospitalized multiple times I've done ketamine treatments and ECT and literally every drug on the market some of which have had horrifying side effects. Viibryd actually works, for the first time in my life I know what it's like to have just a mild level of depression. I'm able to perform activities of daily living, stay on top of housework and try reconnecting with friends and family that I just haven't had the energy to have relationships with in years.
It's a devastating choice that I have to make, I'm not sure what I'm going to do but weight gain at this rate is not healthy and certainly impacts my body image. I've tried increasing my exercise, I'm sticking to a post gastric bypass diet and doing my very best to resist the urge to eat the crap but sometimes I almost feel like I'm doing it mindlessly without recognizing it. And that's borderline terrifying.
So either I jeopardize my physical health and well-being by gaining excessive amounts of weight and putting myself at higher risk for cardiovascular disease, liver disease etc or stop taking the Viibryd and put my life at risk by increasing my risk of suicide.
Yes. After starting viibryd, I gained 15lbs over 3 months. My activity level didn't change. What I ate didn't change. The only thing new in my life was high dose viibryd. I couldn't figure out what was going on. Now I need to make a decision, stop and try something new? Or keep going w a med that works well for me but may make me gain weight... package inserts and professionals don't think it does. But it's a relatively new drug...
These reviews and comments really helped me with this issue, so thanks everyone. They also motivated me to add my own experience to the collection:
I too gained weight on Viibryd. I understand that this is a relatively unusual side effect, so I wouldn't recommend that anyone avoid trying the drug based on my experience (or on the number of reviews here). That said, I gained about 20 lbs. in roughly 5 months after I started taking this drug. I used the starter pack (10mg, up to 20mg) then went up to 40mg after a few weeks. About 4 months after starting the 40mg dose (roughly 5 months total), I started noticing my suits felt tight, and then increasingly so over a few weeks. My feet and ankles were also swollen (bilateral peripheral edema) probably starting a few weeks before I noticed the weight gain. The edema was minor and infrequent at first, but increased in severity, frequency, and duration, which was very alarming.
I was initially worried it was my heart (I'm 36 and generally in good health). The psych doc and I didn't jump to Viibryd as the cause right away because of the studies indicating it doesn't cause weight gain. I also hadn't noticed it at first, and hadn't gained weight when I was on an SSRI a few years ago. But after some labs and a check up with my internist (and her consult) we decided I should taper off the Viibryd.
I decreased the dose every week or so, first to 20mg/day, then eventually down to 10mg every 2 days, and stopped completely a few days ago. In that time (about 4 weeks), I've lost 15 lbs. Granted, I've also changed to a somewhat healthier diet (whatever the cause, the weight gain was a wake-up call for me, health-wise), but not anything drastic. The edema has also disappeared entirely.
Incidentally, I also had pretty frequent and intense "brain zaps" with this drug (before I heard that term, I called them something like "nerve jolts") from pretty much the initial dose to the very moment I'm typing this (4 days after my last dose). They aren't constant or painful, just a little distracting, and probably would not have caused me to stop taking it. I did not have the sexual side effects that are common with SSRIs, nor did I notice any other significant side effects.
As for other meds, I have also taken Adderrall for ADHD for several years. I'm not on any other medications, nor was I before starting Viibryd or after tapering off. Awhile back, I took citalopram (Celexa) for about 2 years, but stopped that over 3 years before starting Viibryd. Interestingly, I did NOT gain weight on citalopram/Celexa, but DID eventually have sexual side effects, just the opposite of Viibryd.
I hope someone finds this helpful. Best wishes.
I can't believe how many reviews on Viibryd are hitting a nerve with me after a good five years of being on this AD. I take 40 mg daily and have always had a sweet tooth, but the cravings have gone through the roof! I cannot seem to pass a drugstore without running in for a sugar fix. And then I eat the whole bag of whatever I buy. It is certainly not helping the depression, or my pocketbook! I've gone up two sizes and am working on the next. I just never realized that it was from the meds until I read these reviews. In addition, I have terrible hot flashes, I drop and spill things, run into walls and bruise myself constantly. I also dream vividly and cannot wake up if I miss a dose. The latest thing is major hair loss. What next? I can't even find a psychiatrist who is taking new patients so I can make a switch. It's maddening. I've tried tapering off this drug because it is so expensive, but I just sink further into the abyss. Surely there is a better way.
I've recently started Viibryd only 2 weeks ago at 20mg and I've already noticed a change in bloating, weight gain, insomnia. I loved Prozac 40mg, the sexual side effects lead me to try this, although my sex drive is back but I still not interested in taking viibryd . I noticed a big change in mood also. It's just not for me.
I've been on Viibryd for almost 3 months now, 40 mg. I have gained almost 30lbs in the past 2 months since I went from the 10 mg to 40mg. I dont care that the side effects say it doesnt cause weight gain, its a lie. My weight gain isnt normal weight gain, its water retention. My ankle had swelled and I then noticed on my legs dents in my skin. My skin wont bounce back, if you push on it, my fingers will leave dents. My doctor and I dont want to switch to something else because its the only medication that has helped me but Im not willing to continue gaining weight. Im physically and emotionally hurting because of this medication. I've also noticed i get brain zaps with this medication, It feels like my brain is being shocked by electricity. Anyways, this medication is horrible in the weight gain/ water retention area but great for what its actually supposed to do.
For me Viibryd definitely caused a weight gain. I gained 60 pounds. I was on 40 mg. I was doing better with my depression and so my dr had me tapper off of the med. I got off of it about 5 weeks ago. I went on a week long vacation an I have been eating high calorie stuff since going off of Viibryd. I am starting a weight loss program and so was trying not to lose before the challenge started. A lost 15 pounds during those 5 weeks. I also had swelling of my ankles with Viibryd. The medication did its job but with unwanted side effects.
Wow... how did I miss these posts? I searched for answers to this question back in October 2011. I've been on Viibryd since then. I have finally found a new dr. who is switching me back to Celexa (which I switched from due to sweating... I'd rather sweat).
Since on Viibryd, I've only gained 10 lbs in a little over a year and a half. HOWEVER, I workout 6 hours a week (kickboxing, running, Insanity, I mean I workout HARD). My craving for sugar skyrocketed winter 2012 and now it all makes sense. I knew this stuff was evil. I also had severe concentration issues and had to be put on adderal, which I am now weaning off of.
Thanks to all that posted. I'm not alone. And when you have depression/anxiety, that knowledge alone is very helpful.
YES! I went off after over a year on it and i gained 20lbs. It made me crave sweets especially and i was starving all the time. As soon as I started weening off I was not starving anymore. It was the only highlight of the horrible weening off and withdrawals i had (and am still having) trying to come off. Im on my 4th week without them and it's much better now. If you read more messages, you will see that most people gained weight. I tried curbing it but it was not easy and I was not successful. Good luck.
I have been taking vybriid for a year now. I started when I was 170lbs now I am 231lbs. The medication is working but planning to go off. When I go to the gym I'm tired and not motivated. I eat all day at work and home.
Yes, I have been on a little more than a year and gained 10-12 pounds, plus watch my lipids go up. I was on mirtazapine for sleep some years ago and the experience was similar: only a little change initially, but seemed to gradually worsen over time. Like others I eat mainly veges and whole grains, and exercise regularly.
I think the problem is that these drugs are approved on the basis of relatively short term studies. In the mix of patients there are probably some who do lose weight initially for a variety of reasons, which muddies the waters. There is a single one year open label uncontrolled study in the literature in which patients had a mean increase weight of 1.7 kg over one yr.
If you are stopping the drug because of this, may I suggest you ask your MD to file a "MedWatch" with the FDA so this can get on the radar screen of the regulators and the sponsor. In full disclosure, yes I am in the "biz" but not in any way in a competitive situation with sponsors of anti-depressants.
I have been on the drug since last October and have been gradually gaining weight. Sometimes my weight goes up a little in the winter, so I wasn't that worried about it, but it isn't coming down, and now it is May. I'm not starving and don't crave anything. I have been watching what I eat and working out the way I always do, but the weight is stuck. Now that I am reading about swelling/bloating, vivid dreams and lipid levels, I am convinced the drug has something to do with it. My knees have always been a problem, but I think the swelling has something to do with them being worse (also the weight gain). Just had my physical and my cholesterol is up to 215 - it has been steady (below 200) for years and years. I am getting off of this drug. Never could really tell a difference anyway. Thanks for posting!
First off, I would like to thank everyone who mentioned gaining weight on Viibryd, cuz I no longer feel like a lunatic! For the first month I took the Viibryd Titration Pack, and I experienced severe nausea (although it was less severe if I ate when I took it), trouble sleeping, and abnormally vivid dreams. But for me, those side-effects went away when I was done with the pack; after 1 month. Then I was taking 40 mg per day. On this dose, I gained 86 lbs in 6 months! I had not changed my diet. I even did the Tapout XT workout and was only able to lose 1 lb! I spoke to both my psychiatrist and my GP, and they both swore that it was impossible for my weight gain to be attributed to the Viibryd. I was even put on a thyroid medication, cuz they were sure my weight gain was due to "stress." But I continued to gain, and stopped that medication.
I am still on Viibryd, and although I have stopped gaining, I am unable to lose! I have contacted the FDA to make sure they are aware of this side-effect, and I urge anyone else who has experienced weight gain, to do so as well. And I will be speaking with my psychiatrist to either go off the medication, or add something for weight-loss. Viibryd has helped my depression a little, but I still experience it on a daily basis, and just came out of another Major Depressive Episode. For me, Viibryd is not worth the weight gain.
I am in the counseling industry soon to have my Doctorate in Psychology. I also suffer with Major Depressive Disorder, General Anxiety Disorder and Post Traumatic Stress Disorder. I have spent years working on stabilizing with medication and therapy, which helps me to have empathy and a full understanding of what my own patients may experience. I have struggled with weight issues most of my life, however with hard work and exercise found I could keep myself at a healthy and attractive weight.
I had been on Effexor for years, taking 375 mg. Last year my depression seemed to progressively worsen, plummeting me into a place I hadn't been in years. I had to discontinue seeing patients because of my own instability for the first time. It was a terrifying experience because I also did not want to go through the stages of trying new medication, although I knew there was probably no other alternative.
My psychiatrist and I discussed a plan. This plan included tapering very slowly off Effexor, even to the point of going down to 37.5 mg. for over a week, to avoid drastic side effects. In the meantime, I went on the starter packet of Viibryd increasing my dosage as planned by the manufacturer from 10mg to my final doage of 40 mg. I was closely monitored by my psychiatrist and "yes" a therapist. I believe to be a good and effective counselor, I must also have enough wisdom to recognize I need to be stable to be effective for my patients.
Here is what I noted in experience and literature thus so far. Like most of the audience, I was told this drug did not have a side effect of weight gain. In fact, insomnia was a noted symptom, along with agitation, and mania. I did not experience insomnia, since on Effexor I had insomnia for over seven years. On Viibryd, I finally slept all night, for the first time. This contradicted what the manufacter had found. I found myself to be more talkative and duly noted to me by others. I was also told by my husband that I was substancially irritable, which is not my usual nature.
I had bouts of mania and grandios thoughts, racing thoughts. I have also had extremely bad vivid dreams.
Lastly, for me, was weight gain. I had just started into my nutrition program again. I only eat organic food,and drink lots of purified water. I was actually beginning to exercise again. I was hoping Viibryd was going to be my solution drug, but alas, real weight gain began.
As I can see by the responses, I am not the only one who had gained weight but also I am not the only one weight gain had a huge impact on their depression. I began craving sweets. My appetite did not overly increase as some had stated, however even on stevia and natural sweeteners, such as found in unrefined coconut oil ( small amounts), I found my weight had increased a significant seven pounds this month.
I asked the psychiatrist about the weight gain and read the manufacturer's reviews which stated weight gain was not a side effect. I also kept in mind the drug is fairly new and some people may have adverse reaction and gain weight. All I can say is the scales are tipping and I am not happy seeing this increase. I am also on daily diuretics which usually eliminate water retention. The diuretics are not effective and I am notably swollen all the time. As noted by another commenter, I too, have gained a large amount in my abdomen, leaving me feel angry, frustrated, and my depression has some what back sliden.
I have continued monitoring my emotional status which seem to almost swing from emotional sadness to a manic. For the record, I am not, nor have I ever had BiPolar Disorder. As mentioned, I am being monitored closely by professional staff and colleagues. This medication is not going to work for me, due to abrupt mood swings and equally important the weight gain. Thank you for this blog. I am going to share this with my psychiatrist to show him weight gain has been a huge impact on many of you. I am going to try stabilizing on organic eating and exercise. Once off everything if the depression can not be naturally controlled, I will obviously have to find another medication which has less drastic side effects.
Sometimes, it isn't always medication change, but what we are also ingesting in this toxic world. For me, natural and conventional medicine go hand in hand. Obesity adds to my already complicated depression. Thankfully, I have a good team of doctors, friends, and colleagues who are all helping me to stabilize. I did not want to risk gaining anymore weight, as that will worsen my situation. Please note, this is what I have decided to do for me. Always use good judgment and have your doctor assist you in making informative decisions which will work for you as an individual and not what each of us has decided to do for ourselves.
Thank you so much for your articulate and detailed description of your experience on Viibryd. I too intend to use the feedback I have read here to discuss my medication with my psychiatrist. I thought this would be the miracle I was looking for. I suffer from the same disorders (plus a couple more) and my depression is refractory. This is the first medication that actually worked for me! Although, it has not helped very much, and I have had many unpleasant side-effects. I am considering alternative treatments now, because I cannot handle this drug. I wish you all the best on your quest for mental health, and thanks again for sharing!
I've been on an increasing g dose of Viibryd to where I've been on 40mg for 3 or 4 months. In that time my weight has shot up 28 pounds! I'm a fairly healthy eater and have never had a gain of that magnitude in a short amount of time.
I even started Weight Watchers 1 1/2 months ago.. I've lost only 1.3lbs to date. I follow it to the T and I constantly struggle in a fight with my weight I think I am losing.
Definitely talk you your doctor about switching meds, I certainly am!!
Yes, I experienced significant weight gain on Viibryd. Twenty pounds in two months. Will power and self control regards sugar and carbs went out the window. Cravings were much more than I ever experienced and off of the charts. I have tapered down from 40 mg. to 10 mg. and will soon be Viibryd free. Viibryd also caused tremendous tightness and soreness in my lower leg tendons which cannot be attributed to anything else. In addition, I slept very poorly on Viibryd and it took a full four weeks to feel anything. It had too much of a "zombie" effect on me. I turned into a "whatever" person like oh . . . I don't feel like brushing my teeth or showering until 2 pm today because I am so lethargic. I think being on Viibryd is worse than major depressive disorder, seriously. Think twice before continuing or starting on this drug. They only tested it for 8 weeks on a very few people. It should be pulled from the market.
Ineffective and to my way of thinking - dangerous. I cannot emphasize enough that this drug is a problem causer on many levels. Buyer be aware.
wow, not sure how i missed this comment a few months ago when i was looking for specifics on viibryd prior to starting on January 18th of this year... i started on 10 mg, quickly (like 11 days later) went to 20 mg. i just bumped to 40 mg this past Friday, per instruction of my psychiatrist, as I'd left her messages the night before in major, major distress... she is 65 and still does CTE for Pharmacology- she is very big on trying the new stuff and really just goes by what colleagues and patients share with her... i have to say, and i did say this to my doctor, who I see every 2 weeks, I told her i felt no real difference, but at the time i started it, i was not in distress or severely depressed. In the past I have always started an anti-d while in the midst of crisis, and i was very easilyi able to tell when the meds were kicking in (zoloft, effexor xr, and most recently came off of 3 years of celexa a year ago this time)...
I added wellbutrin a couple of weeks ago... i had taken it for a short while last year and after 6-8 weeks i ditched it because I did not feel better than i did on celexa, and felt very "muted", i guess a bit zombie-ish, u might say, but it did really curb my terrible smoking habit, i'd just about quit.
i have not yet had a weight gain with viibryd, but i will say for sure i really have to be careful and watch it, because a sweet tooth i haven't had in over 20 years (I am 42) is back with a vengeance!! When I stop for my Dunkin Donuts coffee, i am now more often than not, getting a donut or 2, totally not like me at all...
unfortunately, i am finding the "whatever" bug has bit my a**, too... i am not digging it, either, because all of the discipline in the world doesn't seem to work... i started off the new year on luvox after taking a break and taking nothing for 8 months, but after 11 days i had gained 8.5 lbs, i could not stop eating, needless to say, yeah, that one had to go!
I am feeling like "Oh ok, now what do i try?" I keep hitting walls. : ( Any suggestions are welcome and will stick with Vii for now.
Related topics
depression, weight loss (obesity/overweight), weight, viibryd
Further information
- Viibryd uses and safety info
- Viibryd prescribing info & package insert (for Health Professionals)
- Side effects of Viibryd (detailed)
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