Can prednisone cause shortness of breath?

I agree with the previous comment. Predinsone has been my best and quickest cure for breath shortness so check for other causes or go see a doc

Hello. Prednisone will not cause shortness of breath. It is given to me to prevent shortness. Sounds like oxygen problem or pneumonia. Get in to a doc as soon as you can. If she is not able to finish a sentence or gasps between words, get to an ER. She may be sick of hospitals (I am) but not her call. You can also go to a major pharmacy and pick up a pulseox for about fifty dollars to check her oxygen if you are in US.

Let us know what the doc says.

While "trouble breathing" is listed as an allergic reaction, this sounds more like something that isn't a sudden change. Prednisone can cause fluid retention, which can cause shortness of breath. In either event she should see her doc. If its fluid there are things can be done and if it is an allergic reaction he has to know it.