I took Effexor XR for many years..well over ten years. Never took more than 75 mg. Last May I had a bleeding stroke due to high blood pressure. At the time I was taking a blood thinner and drugs like Advil and Aleve which may have contributed to the bleed. Because Effexor XR can and does raise blood pressure I needed to exchange it for Zoloft. The SSRI drugs are not good for me and I would love to know if any of you have had blood pressure problems with Effexor XR. I miss it.