Duloxetine - How long does it take for Cymbalta to kick in?

"Sleep, energy, or appetite may show some improvement within the first 1-3 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve."
This also applies to pain management although it was written for depression.

I started taking Duloxetine about a week ago for nerve pain caused by a major motorcycle accident. I also take Gabapentin (300 mgs - 3 times a day). Thus far, no side effects, yet no benefits from this new drug. I have been reading that it can take a month or more to work. Is this true?

Cymbalta is a wonderful drug when it works. It can help with anxiety and studies have shown that it is effective for relief of chronic pain from fibro and other conditions. It also helps with depression. Usually people start noticing a difference in about 3 - 4 weeks, the full effects of the med will take around 2 months. After 2 months, if you don't notice any difference in your symptoms or if the side effects are very bothersome, talk to your doc about upping the dose or switching to something else, like bupropion (Wellbutrin). I really hope this med helps you and that you'll have less high pain days. Don't be afraid to ask your doc any questions, that's what he or she is there for. Sending you gentle hugs, my love and my light!!

Cymbalta needs to build up in your system. Usually after 2 weeks it starts to work, but can sometimes take up to a month.