I have been on synthroid for about 2 1/2 months. They started me out at .25, and I was super energetic, had insomnia, and gained weight. Then they upped my dosage (a month ago) to .50-my thyroid levels are normal now BUT I have had major problems with depression, and irritibility, and mood swings. I am on some other medication for bi-polar disorder, so I don't know if my body is processing them faster, or if the synthroid is causing my depression to come back. Are there any other alternatives for synthroid? Any advice would be helpful!