Can I take Cymbalta at night? It makes me too tired when I take it in the morning?

From what I can see, Silenor isn't a good mix with Cymbalta since it can cause serotonin syndrome. If you check the "symptom checker" at the top of this web site you can see more details about the mix. I'm not sure what the other drug is you're taking. I tried 30mg of Cymblata at night first because it can cause drowsiness but the insomnia was so severe I had to switch to mornings. After a few days I was less tired and now feel my "normal" tired again(I'm always so very tired so it's a bit hard for me to tell what's doing it). So may be worthwhile trying it for a few days. I also take Ativan and Zopiclone for insomnia.

Prudence,
I have tried taking it in the morning and at bedtime and I prefer taking it at bedtime to help me sleep. And if it makes you sleepy, by all means I recommend you to take it early in the evening so you won't be so "hung over in the mornings". I have chronic fatigue, as well as fibro and miss out on a couple of stages of sleep per my sleep study so I take almost all of my meds at night and still don't sleep very well. Good luck!

Yes, the positive effects will last throughout the night and day whether you take it at night or in the morning. It builds to a certain level in your blood and as long as you take it on schedule it will be working. You may find after being on it for awhile that you'll want to change back to dosing in the morning as it can cause insomnia. Just gonna have to give it a try.