I was prescribed 20 mg olanzapine on 9/25 and then changed to 10 mg on 9/27... can I cut the 20mg in half. (30 tabs) and if not, why not? very expensive... $238.98.. just to throw in trash?
Can I cut olanzapine 20 mg tabs in half?
Question posted by coonsi on 29 Sep 2017
Last updated on 15 August 2018 by ATAKMANGA
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Answers
ATAKMANGA
15 Aug 2018
In theory, yes. However, the center oxidizes and breaks down in a few days to a few weeks. This is why it has an enteric coating and not recommended for splitting or crushing. So while it may be ok to split if both halves are taken in the same day, splitting could cause the medication to break down if left exposed to the air for too long.
Stephen Treloar
30 Sep 2017
A pharmacist would probably say no (they want you to purchase a new script) and they (Zyprexa) do (or did) used to have a smooth white coating over yellow insides; I guess I know that because I must have tried. I don't recall any issues and they still worked the same. They are not an extended release tablet but they may be coated to prevent extended exposure to stomach acid. The FDA document does not say one way or another.
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Further information
- Olanzapine uses and safety info
- Olanzapine prescribing info & package insert (for Health Professionals)
- Side effects of Olanzapine (detailed)
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