Does clindamycin HCL usually make a patient very tired?

Yes! I was prescribed clindamycin 3 times a day after a tooth extraction last Friday and am so tired. If I’m not sleeping, I’m yawning. 2 more days to go and can’t wait to be done.

Good to see answers. Want to add I was told to take 2 probiotics a day with it to help with possible stomach issues, and I also have yogurt. Hope this helps others.

I’m taking, and have been on Clindamycin, 300 mg 4 times/day for this odd peritonsillar abscess diagnosed 3/10/24. I’m 69 years old, had a viral sore throat and what I thought was a terrible earache- Strep negative. Went back 5 days later c/o continued pain, diagnosed with PTA. The fatigue is unreal. I thought it was the time change, but turning clocks back one hour never really affected me. I still work 24 hours/week as Unit Coordinator on busy Med/Surg Unit. I wear a mask (not mandatory). I won’t take 4 time/day dose I’d probably be comatose LOL! Suppose to take for 10 days…glad to hear I’m not alone with the profound fatigue issue!

Well that's what I was wondering, I have been on clindamycin for 2 days and I thought I had "sleeping sickness " I Google it and was shocked at the side effects, but nowhere was it mentioned about drowsiness or excessive sleepiness!! That's all I have done for 2 days and it totally wipes me out just to get out of my chair!! I was so grateful to read the comments and find out I'm not alone with this!! I hate taking medications anyway but this is ridiculous!! Good luck

I am on day 7 of this antibiotic and have tried to find out why clindamycin makes me soooo exhausted every time I take it? I found the Drugs.com community. Happy to hear I am not the only one feeling so terrible after taking clindamycin. Sad that we all have to feel like this. How does this information reach the maker of clindamycin?

So happy I found this thread! I just started taking it and couldn’t figure out why I was so tired. Like another user said, I’ve been testing for covid-19 because that’s how exhausted I feel.

Like many of these answers, I am so glad I read through everyone else's comments.
Nowhere did it say on the drug leaflet anything about tiredness. I am on day 2 and just want to nap and am constantly yawning. I am always on the go, but not this week. I was also prescribed this for tooth/gum pain... so tired !

I fell asleep reading these answers after taking my morning dose of clindamycin... yep, sleepy, tired, no energy, extreme malaise.

Thanks people!!! NOW it all makes sense to me after reading ALL these reviews on Clindamycin! IF I had known this I would have avoided taking it. I looked up this certain drug after having such a hard time with my tooth. Come to find out … it’s this drug!! This makes a person lethargic and weak. AND… it says nothing on the label about it making a person very drowsy.
This needs to be revised… OR this should not even be subscribed to anyone!!

I have been taking this medication for 6 days and feel like I cannot stay awake for more than a few hours. I’m taking 450mg 3 times a day and couldn’t figure out why I have done nothing but sleep all week.

I’ve been taking Clindamycin for the past two days now for an infection following a tooth extraction, and it is most definitely wearing me out! I was exhausted to begin with due to the severe pain from the infection, but now that the pain is mostly gone, I’m feeling lethargic at a much stronger level. I’m fortunate I can nap during the day if I need to, and I certainly do! I’ve read others’ comments about the exhaustion being caused by your good bacteria being depleted due to the antibiotic, so I may try to drink some kefir to restore the balance. I have also noticed that my skin is very dry, so I suspect I’m dehydrated, as well. I hope this comment is helpful to whomever reads it. May we all be well and on the mend soon!

Thank you, thank you, thank you everyone for talking about this! I thought I was loosing my mind! I even tested my self for Covid, with NO other symptoms, because I’m so tired!
This med side effects need to be updated for sure!
A few more days to go
Just AWFUL!

I'm glad that I found this discussion. I have been taking Clindamycin for a few days for a tooth abscess, I have been so fatigued that I can hardly function. Today is Sunday and I'm going back to the dentist on Tuesday. I am stopping taking any additional Clindamycin.

I’ve been on clindamycin for two days and I’m totally exhausted can’t stay awake. The stomach upset is pretty bad. I have GBS infection and this is the third antibiotic that I’m taking. I feel terrible. Anyone else feeling bad?

I started this medication yesterday and I cannot keep my eyes open. I looked up the side affects and it was not one of them. They need to update this study because I feel so tired I cannot keep my eyes open.