It should not make me gain weight but I believe it is. I was taking Lexapro for a year and I gained over 20 pounds and it made me depressed and self conscious. I came off of the medication and lost the 20 pounds in a few months. I explained to my doctor that I was still suffering from anxiety, but I was nervous for a new medication to make me gain the weight back. She assured me buspirone would not make me gain any weight, but I have gained almost 7 pounds in the last month or so. Has anyone else had any experience with this?