Is it okay if I took Benadryl and amitriptyline at the same time?

Interactions between your drugs
Moderate
amitriptyline diphenhydrAMINE
Applies to: amitriptyline, Benadryl (diphenhydramine)

Using amitriptyline together with diphenhydrAMINE may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with a debilitating condition. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Other drug and disease interactions
Benadryl (diphenhydramine) interacts with more than 300 other drugs and 8 diseases.
amitriptyline interacts with more than 600 other drugs and more than 20 diseases.
Drug and food interactions
No results found in our database - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.

Therapeutic duplication warnings
No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

https://www.drugs.com/interactions-check.php?drug_list=896-1617,168-0