... other buffers,i have a damaged liver and need something after a surgical procedure but does hydrocodone come by itself, no buffers added??
Acetaminophen/Hydrocodone - is there hydrocodone without any buffer(acetaminophen, or aspirin, or?
Question posted by jbitters on 27 April 2011
Last updated on 31 October 2013 by Anonymous
3 Answers
Inactive
31 Oct 2013
Oxycodone is Percocet without the ascetaminaphin. Percocet is Oxycodone with ascetaminaphin. If you have a damaged liver, simply request Oxycodone instead of Percocet., and you won't be getting any ascetaminaphin.
sparkyair
16 Dec 2011
The liver and the kidneys clear toxins and chemicals from the body. However, some medications can affect the function of these organs. The Hospice website notes that nonprescription analgesic drugs such as ibuprofen can cause or worsen problems in the liver and kidneys. Ibuprofen is a nonsteroidal anti-inflammatory drug, or NSAID, that is used to relieve pain and reduce fever and inflammation.
Liver Effects
Up to 15 percent of patients taking NSAIDs such as ibuprofen may experience mild elevations in liver, or hepatic, tests, warns RxList. These lab test abnormalities may be temporary or worsen with continued use of these painkillers. RxList also notes that in rare cases, severe hepatic effects such as jaundice, liver necrosis, or cell death, and even liver failure may occur.
sparkyair
16 Dec 2011
Role of the Liver
The liver takes up drugs and oxidizes them using cytochrome P450 enzymes. There are many of these iron-containing enzymes and each type is specialized for oxidizing certain types of chemicals.
Here are some features of the system:
Oxidation of the drugs usually makes them more water soluble or hydrophilic. Hydrophilic compounds are filtered more easily into the kidney tubules than hydrophobic ones.
Many of the P450 enzymes are adaptive- that is, exposure to a certain drug will cause greater production of the enzyme that attacks the drug.
The P450 enzymes have side reactions that produce compounds that are toxic to the liver. Thus prolonged high level use of any drug may damage the liver.
The liver has other methods of detoxifying drugs in addition to the P450 system. For example, many drugs are conjugated by attaching various molecules to their side chains.
Role of the Kidney:
Most drugs are small and if they are hydrophilic they will be filtered across the glomerular membranes into the kidney tubules. If a drug is bound to a plasma protein less of it will be filtered and it may stay in the body for a long time.
Many things can happen to the filtered drug:
Since drugs are foreign substances, most are not reabsorbed actively and often they are rapidly eliminated in the urine. If a drug is reabsorbed it will be eliminated slower.
Some drugs are actively secreted into the tubules. There are transporters for secreting both organic acids and organic bases (many drugs fit one of these categories). A secreted drug will be eliminated faster than a similar one which is not secreted.
Sometimes we can manipulate the kidney to get faster elimination. In aspirin poisoning, for example, bicarbonate is sometimes given to make the blood more alkaline. This ionizes the aspirin and the ionized aspirin is reabsorbed more slowly from the kidney tubule- it stays in the tubule and is eliminated.
Robert_325
28 April 2011
They have vicoprofen which is hydrocodone plus ibuprofen rather than acetaminophen. Acetaminophen is metabolized in the liver whereas ibuprofen is metabolized in the kidney. People with liver problems often make this switch. It won't affect your liver. There is no hydrocodone by itself, it's always mixed with something and vicoprofen would be the safest for someone with liver problems if you MUST take it.
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acetaminophen, aspirin, hydrocodone
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