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Dihydrotachysterol Pregnancy and Breastfeeding Warnings

Brand names: DHT, DHT Intensol, Hytakerol

Dihydrotachysterol Pregnancy Warnings

Dihydrotachysterol (vitamin D3) has been assigned to pregnancy category C. There are no controlled data in human pregnancy. Dihydrotachysterol should only be used during pregnancy when benefit outweighs the risk.

Supplementation of vitamin D during the third trimester with vitamin D2 or vitamin D3 has been studied. Dosages of 1000 Intl units per day given daily during the third trimester did not result in any adverse fetal outcome. Neonatal calcium homeostasis was affected, resulting in significantly higher concentrations of calcium, 25-OH vitamin D3, and 1,25-(OH)2 vitamin D3.

Earlier literature expressed concerns over the development of supravalvular aortic stenosis, craniofacial abnormalities, and dental abnormalities in infants and children with idiopathic hypercalcemia. Whether or not prenatal factors predisposed these children to the development of hypercalcemia is not known.

Fifteen hypoparathyroid women receiving 50,000 to 250,000 Intl units of vitamin D2 experienced 27 uneventful births. No cardiovascular or craniofacial abnormalities were reported.

See references

Dihydrotachysterol Breastfeeding Warnings

There are no data on the excretion of dihydrotachysterol into human milk.

See references

References for pregnancy information

  1. Mallet E, Gugi B, Brunelle P, Henocq A, Basuyau JP, Lemeur H (1986) "Vitamin D supplementation in pregnancy: a controlled trial of two methods." Obstet Gynecol, 68, p. 300-4
  2. Lester GE (1986) "Cholecalciferol and placental calcium transport." Fed Proc, 45, p. 2524-7
  3. Delvin EE, Salle BL, Glorieux FH, Adeleine P, David LS (1986) "Vitamin D supplementation during pregnancy: effect on neonatal calcium homeostasis." J Pediatr, 109, p. 328-34
  4. Rowe RD, Cooke RE (1969) "Vitamin D and craniofacial and dental anomalies of supravalvular stenosis." Pediatrics, 43, p. 1-2
  5. Taussig HB (1966) "Possible injury to the cardiovascular system from vitamin D." Ann Intern Med, 65, p. 1195-200
  6. Goodenday LS, Gordon GS (1971) "No risk from vitamin D in pregnancy." Ann Intern Med, 75, p. 807-8
  7. (2001) "Product Information. DHT (dihydrotachysterol)." Roxane Laboratories Inc

References for breastfeeding information

  1. (2001) "Product Information. DHT (dihydrotachysterol)." Roxane Laboratories Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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