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1999 to 2020 Saw Decrease in Mortality Due to Infective Endocarditis

Medically reviewed by Carmen Pope, BPharm. Last updated on Dec 14, 2023.

By Elana Gotkine HealthDay Reporter

THURSDAY, Dec. 14, 2023 -- From 1999 to 2020, there was a decrease in the rate of mortality due to infective endocarditis (IE) overall, but a significant acceleration was seen for those aged 25 to 44 years, according to a study published online Dec. 13 in the Journal of the American Heart Association.

Muchi Ditah Chobufo, M.D., M.P.H., from West Virginia University Heart & Vascular Institute in Morgantown, and colleagues reviewed multiple causes of death data from the U.S. Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research database from 1999 to 2020.

The researchers observed a decline in the IE-related age-adjusted mortality rates between 1999 and 2020. In the age groups 25 to 34 and 35 to 44 years, IE-related crude mortality accelerated significantly (average annual percentage changes, 5.4 and 2.3, respectively), but no change was seen for those aged 45 to 54 years (average annual percentage change, 0.5); a significant decline was seen for those aged ≥55 years. In the 25- to 44-year age group, those with IE had an increase in concomitant substance use disorder as multiple causes of death. In contrast with other states, which had a decline or static trend for IE, the states of Kentucky, Tennessee, and West Virginia showed an acceleration in age-adjusted mortality rates.

"The impact of multipronged harm-reduction programs on IE-related mortality trends in the most productive age groups and in certain states remains to be seen," the authors write.

One author disclosed ties to Abbott.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

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