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Selenium Sulfide (Topical) (Monograph)

Brand names: Selseb, Selsun Blue
Drug class: Astringents, Anti-infective

Medically reviewed by Drugs.com on May 10, 2024. Written by ASHP.

Introduction

Anti-infective; cytostatic and antiseborrheic.

Uses for Selenium Sulfide (Topical)

Dandruff or Seborrheic Dermatitis

Treatment of dandruff and seborrheic dermatitis of the scalp.

Relieve symptoms (itching and flaking of the scalp) associated with dandruff.

Dandruff usually responds to treatment, but tends to relapse if therapy is discontinued. Untreated dandruff is a cosmetic problem; generally no medical disability results.

Pityriasis (Tinea) Versicolor

Treatment of pityriasis (tinea) versicolor caused by Malassezia furfur (Pityrosporum ovale).

Topical antifungals usually effective; an oral antifungal (with or without a topical antifungal) may be necessary in patients who have extensive or severe infections or those who have failed to respond to or have frequent relapses with topical therapy.

Selenium Sulfide (Topical) Dosage and Administration

Administration

Topical Administration

Apply lotion or shampoo topically to the skin; apply shampoo or lotion (as a shampoo) topically to the hair and scalp.

For external use only. Avoid contact with eyes; do not apply to broken skin or to infected or inflamed areas. (See Systemic Toxicity under Cautions.)

Shake lotion well before use.

Lotion may damage jewelry; remove all jewelry before using.

For treatment of dandruff and seborrheic dermatitis of the scalp: Massage into wet scalp. Wait 2–3 minutes, then thoroughly rinse scalp. Repeat application and rinse procedures. Wash hands thoroughly following use.

If used before or after bleaching, tinting, or permanent waving of the hair, rinse hair with cool water for at least 5 minutes after applying lotion or shampoo.

For treatment of tinea versicolor: Apply sufficient quantity topically to the affected skin; apply a small amount of water concurrently to form a lather. Allow to remain on the skin for 10 minutes following application, then rinse skin thoroughly.

Dosage

Pediatric Patients

Dandruff or Seborrheic Dermatitis
Topical

Children ≥2 years of age: Initially, apply 5–10 mL of 2.5% lotion (as a shampoo) twice weekly for 2 weeks. For maintenance, apply once every 1–4 weeks.

Children ≥2 years of age (as self-medication): Apply a small amount of 1% lotion as a shampoo once or twice weekly. For maximum control, use every time patient usually shampoos hair and scalp.

Pityriasis (Tinea) Versicolor
Topical

Children ≥2 years of age: Apply 2.5% lotion to affected areas once daily for 7 days.

Adults

Dandruff or Seborrheic Dermatitis
Topical

Initially, apply 2.25% shampoo or 5–10 mL of 2.5% lotion (as a shampoo) twice weekly for 2 weeks. For maintenance, apply once every 1–4 weeks.

For self-medication, apply a small amount of 1% lotion as a shampoo once or twice weekly. For maximum control, use every time patient usually shampoos hair and scalp.

Pityriasis (Tinea) Versicolor
Topical

Apply 2.25% shampoo or 2.5% lotion to affected areas once daily for 7 days.

Special Populations

No special population dosage recommendations at this time.

Cautions for Selenium Sulfide (Topical)

Contraindications

Warnings/Precautions

Warnings

Hair and Scalp Conditions

Oiliness or dryness of the hair and scalp may occur. Rebound oiliness of the scalp reported.

Discoloration of various shades of natural and dyed hair has occurred; minimize or prevent by rinsing hair thoroughly after treatment.

Diffuse hair loss reported; resolved 1–2 weeks after discontinuance of the drug.

Sensitivity Reactions

Hypersensitivity Reactions

Hypersensitivity reactions have occurred. If irritation or sensitivity occurs, discontinue drug.

General Precautions

Systemic Toxicity

Risk of systemic toxicity following topical application to damaged skin.

Do not use if acute inflammation or exudation present; risk of increased absorption.

Do not apply to damaged skin (e.g., open lesions or acute inflammation or exudation of the scalp).

Localized Burning or Irritation

Contact with eyes, genital area, or in skin folds may cause burning and irritation. If contact with the eyes occurs, rinse eyes thoroughly with water; thoroughly rinse genital area and skin folds following topical application of the drug.

Specific Populations

Pregnancy

Category C.

Lactation

Not known whether topical selenium sulfide is distributed into milk. Use with caution in nursing women.

Pediatric Use

Safety and efficacy of 2.5% lotion not established in infants.

Safety and efficacy of 1% lotion for self-medication not established in children <2 years of age.

Safety and efficacy of 2.25% shampoo not established in children.

Common Adverse Effects

Skin irritation, increased hair loss, discoloration of hair, oiliness or dryness of hair and scalp.

Selenium Sulfide (Topical) Pharmacokinetics

Absorption

Not absorbed following topical application of the 1% lotion to intact skin of the scalp during usual shampooing conditions.

Percutaneous absorption may occur following topical application to damaged skin. (See Systemic Toxicity under Cautions.)

Distribution

Extent

Not known whether topical selenium sulfide crosses the placenta or is distributed into milk.

Stability

Storage

Topical

Lotion

Tight container at 15–30°C. Protect from heat; do not freeze.

Shampoo

15–30°C; do not freeze.

Actions and Spectrum

Advice to Patients

Additional Information

The American Society of Health-System Pharmacists, Inc. represents that the information provided in the accompanying monograph was formulated with a reasonable standard of care, and in conformity with professional standards in the field. Readers are advised that decisions regarding use of drugs are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and that the information contained in the monograph is provided for informational purposes only. The manufacturer's labeling should be consulted for more detailed information. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information contained in the monograph is not a substitute for medical care.

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Selenium Sulfide

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Topical

Lotion

1%*

Selenium Sulfide

Watson

Selsun Blue

Chattem

2.5%*

Selenium Sulfide

Morton Grove

Shampoo

2.25%

Selseb (with propylene glycol, parabens, and urea)

Doak

AHFS DI Essentials™. © Copyright 2024, Selected Revisions May 10, 2024. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

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