Multiple Vitamins for Infusion Shortage

• • Baxter has Infuvite svailable.
  • Pfizer discontinued M.V.I. presentations in October 2021.

• • Infuvite injection, Baxter, Adult, 2 x 5 mL single dose vial, 100 count, NDC 05464-3564-91
  • Infuvite injection, Baxter, Adult, 2 x 50 mL bulk vial, 10 count, NDC 05464-3565-02
  • Infuvite injection, Baxter, Pediatric, 5 mL single dose vial, 100 count, NDC 05464-3564-61
  • Infuvite injection, Baxter, Pediatric, 50 mL bulk vial, 1 count, NDC 05464-3564-70

Estimated Resupply Dates

• • Baxter has all Infuvite presentations available.

Alternative Agents & Management

• • The American Society for Parenteral and Enteral Nutrition (ASPEN) has detailed recommendations for managing an intravenous multivitamin shortage in adults and pediatric patients: https://www.nutritioncare.org/Guidelines_and_Clinical_Resources/Product_Shortages/2021_Parenteral_Nutrition_Multivitamin_Product_Shortage_Considerations/
  • Key recommendations include:
  • Use oral or enteral multivitamin preparations whenever possible.
  • Use of pediatric intravenous multivitamins for adults is not recommended and may result in a shortage of pediatric products.
  • Use of multivitamin preparations without vitamin K is fine with individual supplementation of Vitamin K products. Ensure patients receiving vitamin K are getting adequate anticoagulation if they are on warfarin.
  • Reserve intravenous multivitamins for patients receiving parenteral nutrition.
  • Reserve pediatric intravenous multivitamins for children less than 2.5 kg or less than 36 weeks gestational age. Consider using 5 mL of adult intravenous multivitamins in children weighing greater than or equal to 2.5 kg or gestational age of 36 weeks or older. Supplement intravenous vitamin K (total daily dose = 200 mcg).
  • If no pediatric intravenous multivitamins are available, infants less than 2.5 kg or less than 36 weeks gestation should receive adult intravenous multivitamin at a daily dose of 1 mL/kg up to a maximum of 2.5 mL per day. Supplement intravenous vitamin K daily (total daily dose = 200 mcg).
  • When all supply options are exhausted, ration intravenous multivitamins in parenteral nutrition or administer individual parenteral vitamins.
  • Purchase only the supply needed, do not stockpile.
  • Use oral products when appropriate, however review the oral product to ensure it contains sufficient amounts of essential vitamins (eg, folate, thiamine). Oral vitamin products are considered dietary supplements and are not approved by FDA. Availability and contents of these products varies widely. Components can change at any time.