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Prasugrel Dosage

Medically reviewed by Drugs.com. Last updated on May 30, 2024.

Applies to the following strengths: 10 mg; 5 mg

Usual Adult Dose for Acute Coronary Syndrome

Initial dose: 60 mg orally once
Maintenance dose: 10 mg orally once a day

Comments:


Use: To reduce the rate of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome (ACS) who are to be managed with PCI for unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), or ST segment elevation myocardial infarction (STEMI).

Usual Geriatric Dose for Acute Coronary Syndrome

65 to less than 75 years:


75 years or older: Use is generally not recommended in such patients, except in high-risk situations (e.g., diabetes or prior myocardial infarction) when benefit outweighs risk.

Comments:

Use: To reduce the rate of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome (ACS) who are to be managed with PCI for unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), or ST segment elevation myocardial infarction (STEMI).

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Mild to moderate liver dysfunction (Child-Pugh A and B): No adjustment recommended
Severe liver dysfunction (Child-Pugh C): Not recommended

Dose Adjustments

Patients weighing less than 60 kg:

Precautions

US BOXED WARNING: BLEEDING RISK


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice: Do not break tablets.

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.