Generic name: avatrombopag [ A-va-TROM-boe-pag ]
Drug class: Platelet-stimulating agents

Medically reviewed by Judith Stewart, BPharm. Last updated on Aug 23, 2023.

What is Doptelet?

Doptelet is used to treat thrombocytopenia (a lack of platelets in the blood) in adults with chronic liver disease who are scheduled to undergo a medical procedure.

A low platelet count increases the risk of excessive bleeding during certain medical procedures. Avatrombopag increases the production of platelets by your body to help prevent too much bleeding.

Doptelet is also used to treat low blood platelet counts in adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough.

Doptelet is also used to treat chronic immune thrombocytopenia when other treatments have failed.

Doptelet is not a cure for thrombocytopenia and it will not make your platelet counts normal in adults with chronic liver disease or chronic immune thrombocytopenia.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Doptelet if you are allergic to avatrombopag.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

• a blood clot; or

• a bleeding or blood clotting disorder other than thrombocytopenia.

Your doctor will measure your platelet levels with a blood test before you start taking this medicine.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

You should not breast-feed while using Doptelet, and for at least 2 weeks after your last dose.

How should I take Doptelet?

Take Doptelet exactly as it was prescribed. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take this medicine with food.

Doptelet is usually taken once daily to treat chronic immune thrombocytopenia.

When given before a medical procedure in people with chronic liver disease: Doptelet is usually taken once daily for 5 days, beginning 10 to 13 days before your procedure. Carefully follow your doctor's dosing instructions about the timing of this medicine and the procedure.

Your doctor will measure your platelet levels weekly to determine how long to treat you with avatrombopag. You may also need blood tests for a few weeks after your last dose.

Store at room temperature away from moisture and heat. Keep each tablet in the foil blister pack until you are ready to take a dose.

Dosing information

Usual Adult Dose for Thrombocytopenia:

Chronic Liver Disease:

• Platelet count less than 40 x 10⁹/L: 60 mg orally once a day starting 10 to 13 days prior to the scheduled procedure
• Platelet count 40 to less than 50 x 10⁹/L: 40 mg orally once a day starting 10 to 13 days prior to the scheduled procedure.

Duration of therapy: 5 days

Comments: Patients should undergo their procedure 5 to 8 days after the last dose of this drug.

Use: Treatment of thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a procedure.

Chronic Immune Thrombocytopenia: 20 mg orally once a day. Adjust the dose or frequency of dosing to maintain platelet count greater than or equal to 50 x10⁹/L. Do not exceed 40 mg per day.

What happens if I miss a dose?

For chronic immune thrombocytopenia: Take the missed dose as soon as you remember it. Take your next dose at the regular time and stay on your once-daily schedule. Do not take two doses at one time.

Before a scheduled medical procedure: Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Doptelet side effects

Get emergency medical help if you have signs of an allergic reaction to Doptelet: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You could develop a blood clot while using avatrombopag. Call your doctor or get emergency medical help if you have:

• chest pain, shortness of breath;

• fast heartbeats;

• pain, swelling, or redness in one or both legs;

• stomach pain or tenderness;

• sudden fever or chills, yellowing of your skin or eyes; or

• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common Doptelet side effects may include:

• fever;

• easy bruising or bleeding (nosebleeds, bleeding gums), purple or red spots on your skin;

• feeling tired;

• headache, joint pain;

• cold symptoms such as runny or stuffy nose, sneezing, sore throat;

• nausea, stomach pain; or

• swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Doptelet?

Other drugs may interact with avatrombopag, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Doptelet only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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