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Rezdiffra Disease Interactions

There is 1 disease interaction with Rezdiffra (resmetirom).

Moderate

Resmetirom (applies to Rezdiffra) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Avoid use of resmetirom in patients with decompensated cirrhosis (consistent with moderate to severe liver dysfunction [Child-Pugh B or C]); drug exposure and the risk of adverse reactions are increased in this population. The safety and effectiveness of resmetirom has not been established in patients with NASH cirrhosis. No dosage adjustment is recommended for patients with mild liver dysfunction (Child-Pugh A). Monitor patients during treatment with resmetirom for elevations in liver tests and for the development of liver-related adverse reactions.

References

  1. (2024) "Product Information. Rezdiffra (resmetirom)." Madrigal Pharmaceuticals, Inc.

Rezdiffra drug interactions

There are 135 drug interactions with Rezdiffra (resmetirom).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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