Skip to main content

Methotrexate User Reviews & Ratings (Page 3)

Brand names: Methotrexate LPF Sodium, Trexall, Rasuvo, Otrexup, Xatmep Jylamvo

Methotrexate has an average rating of 6.6 out of 10 from a total of 311 reviews on Drugs.com. 54% of reviewers reported a positive experience, while 23% reported a negative experience.

Reviews for Methotrexate

  • fluff...
  • Taken for 6 months to 1 year
  • April 5, 2013

For Psoriasis "I've had severe psoriasis, which covered me head to toe since I was 5. I'm now 30. Tried every trick in the book from lotions and potions, light therapy, & homeopathic remedies. I put off taking methotrexate for fear of becoming a glow-in-the-dark alien with the side effects! Finally gave in last year and so glad I did. It cleared within 3 weeks. I'm now on 15mg a week and only have slight patches of psoriasis dotted about. Had a few bad headaches now and then but nothing extreme. A little wobbly on the blood tests but nothing life-threatening just yet. Much better quality of life at the moment, and much less hoovering, haha."

9 / 10
Was this helpful?YesNo
110 Report
  • Loss
  • Taken for 1 to 6 months
  • January 14, 2020

For Rheumatoid Arthritis "I was on this medicine. I always google but this one friend insisted that I didn't and just follow doctors order. Worst case scenario I woke up one morning with dizziness and it got severe . I was not light headed or faint just dizziness and not able to function. I was laid up for more than 2 weeks. Due to dizziness . My vital signs were not off, just severe dizziness. This pill has literally caused a life changing experience. I had to close down my registered home day care . I'm not even able to function as I used too. Been off the medication for almost 2 years . but I still get dizziness and double vision , not able to take on any sort of employment because just never know when a flare up will spiked. Yes I already had other health issues. Nerve damage, blood disorders, ringing on both ears. Herniated disc. Doctors should be accountable for prescreening their patients. Si"

1 / 10
Was this helpful?YesNo
54 Report
  • Uk lady
  • Taken for 1 to 6 months
  • August 15, 2012

For Rheumatoid Arthritis "I have only been taking this medicine for a short while and the benefits are good so far. I am still able to keep working as a Paramedic which is physically demanding. Without my 20mg I slowly turn into a statue."

8 / 10
Was this helpful?YesNo
110 Report

Frequently asked questions

  • scaly...
  • Taken for less than 1 month
  • December 30, 2013

For Psoriasis "I have had psoriasis on my scalp since I was a baby with "Cradle Cap.'' It was left untreated until I was about 21. I have tried every cream and t-gel out there. Nothing cleared it up fully. Since I turned 24 the condition has spread to other parts of my body, usually parts that don%u2019t get much light. Psoriasis is terrible and affects everyone so differently. This condition has kept me from getting close to people and even kept me from going to hair dressers. Finally I decided to start this medicine. I'm currently on my fourth week of 15mg oral methotrexate. I have noticed a huge decrease in itching and my patches seem to be not as scaly. I really hope this works, so far so good."

Was this helpful?YesNo
100 Report
  • Anony...
  • Taken for 1 to 6 months
  • July 2, 2018

For Rheumatoid Arthritis "Methotrexate can ruin your lungs very quickly. I now have pulmonary fibrosis because two doctors insisted that it would be fine. They lie and tell you oh you just have interstitial lung disease but it usually stops..Do Not believe them! Take something else!"

1 / 10
Was this helpful?YesNo
64 Report

Are you taking this medicine?

  • Kimber
  • Taken for 1 to 2 years
  • November 4, 2013

For Psoriasis "This drug greatly helped my psoriatic arthritis, but not the plaque poriasis, which always came back. I've been through the scrip topicals, light treatments, Amiveve, etc. I was 98% covered. Why did not a single doctor ever tell me NOT to touch beer???? If you drink beer put it DOWN and see how quickly you begin to clear up. Pork is another culprit as it is slow to digest and effects the immune system. For topical relief? Try OTC Boudreaux's Butt Paste baby diaper rash cream, which far outshines Dovonex. Scalp treatment? Nutrogena T-Gel Shampoo works quickly. If you are severely covered add zinc or zinc supplements to your diet. I haven't gone to a derm in years and I am clear!!!!"

7 / 10
Was this helpful?YesNo
98 Report
  • AndyW
  • September 3, 2015

For Psoriasis "I have been taking a 15 mg weekly dose (three doses of 5 mg at 12 hour intervals once a week) for five weeks now. My psoriasis -- pretty heavy scaling on all joints, and "splatter" over pretty much the whole body, which I've had for 18 years (I'm 51) -- has gone almost completely (still a little bit on elbows, knees, and ankles; hands and rest of body are completely clear). Yes, early days, but hopefully.... My only suggestion is to get empty gelatine capsules (or gelatine substitute if you are vegetarian; harder to get hold of) and put the tablets in them before taking. Helps avoid stomach upset."

10 / 10
Was this helpful?YesNo
84 Report

More FAQ

  • Anonymous
  • March 1, 2012

For Rheumatoid Arthritis "I have been taking the medication sine June 2011 I like it, but I'm always sick. It minimizes the pain and swelling, but it doesn't take it all away. I wake up every morning, and I can hardly move my ankles. I'm way to young to have to deal with this I'm only 22 years old. Some days I feel like I'm suffering, and if I'm sick I can't even walk."

8 / 10
Was this helpful?YesNo
108 Report
  • Leopa...
  • Taken for 6 months to 1 year
  • May 6, 2014

For Psoriasis "I live in the UK & have had plaque psoriasis for 20 yrs. After various lotions, UVB & PUVA, my knees & elbows became infected and I could hardly walk or sleep with the discomfort. As I also have depression, my dermatologist decided on prescribing methotrexate as my quality of life was so severely affected. I take 15mg tablets once a week, within a month it had all but gone, & has remained that way. It has been a year since I started, it's such a relief not to think about my knees all the time! I also take folic acid, & the skin on my face has become quite oily, but it's definitely worth it. I've recently noticed the few patches I have left are beginning to increase in size, but I hope this improves with the arrival of summer!"

9 / 10
Was this helpful?YesNo
93 Report
  • Jenn...
  • June 2, 2015

For Rheumatoid Arthritis "I have been on Methotrexate 25mg for 6 weeks now, but 6 month for 20 mg and I have seen much improvement with my back pain. I do have severe rib and chest pain still, but the back pain is much better. I feel like a zombie though every day I can barely make it through the day. I am so upset about my hair. I have cut almost 6 inches off and still have dry damaged hair from the medicine. I loose handfuls of hair daily and the gi problems sometimes are pretty bad. So I don't know if the side effects out way the benefits. I wish I could have someone help Me fix these side effects and I would be ok. I think the fatigued is one of the worse though. :( ...."

7 / 10
Was this helpful?YesNo
85 Report
  • AnonCat
  • March 19, 2015

For Rheumatoid Arthritis "A couple of years ago my husband was at the point where he was limping severely, with swollen joints in his hands and feet. He was diagnosed with rheumatoid arthritis and began taking methotrexate at 20 mg once a week; he has since cut back to 17.5 mg. It has made a huge difference in his functioning, and he's pretty much back to normal. (Regular strength training at the YMCA has also helped a lot). He was also told to take folic acid once a day, which he does. The only negative is that his hair has thinned quite a bit, which is a common side effect. He is in his 70s."

10 / 10
Was this helpful?YesNo
86 Report
  • Sharr...
  • July 19, 2015

For Rheumatoid Arthritis "I was diagnosed at 10mths old after a knee biopsy. I have been taking methotrexate on & off since I was 16 years old & I am now 41 years old. This medication has greatly reduce the activity of the disease & has increased the quality of my life greatly. I have just changed from methotrexate oral tablets to methotrexate injections. The tablets were making me feel nauseous so my specialist decided to put me on injections to bypass my stomach. The injections are easy to administer & relatively pain free. I am presently just trying to find the right dose for me due to suffering side effects. 15mg has caused me a severely sore lips & mouth, nausea, dizziness, lethargy & abdominal cramps. 12.5mg is the correct dose for me."

8 / 10
Was this helpful?YesNo
83 Report
  • Ronnsy
  • Taken for 10 years or more
  • May 12, 2016

For Rheumatoid Arthritis "After a severe case of Ross River Fever for which i was taking 50 mg Prednisone daily I developed chronic degenerative Polymyalgia Rheumatica, the pain in my arms, neck, hips, knees, hands and ankles was intense and never ending, i tried all the usual pain killers including Oxycontin and Methadone with varying short term success but the mind numbing daily struggle associated with taking Opiates was taking a toll on my life, my Rheum trialed me on 15 mg mtx weekly for 2 months and the result was incredible, the pain in neck and knees almost disappeared after the first week so the Rheum increased dose to 15 mg morning and night once a week, wow what a difference! few side effects and almost pain free, thank you MTX"

9 / 10
Was this helpful?YesNo
76 Report
  • abushy
  • Taken for 1 to 6 months
  • February 27, 2017

For Psoriasis "I was diagnosed with psoriasis about 1.5 years ago at the age of 24. It was severe in my scalp, ears, elbows, hands, knees, legs and feet. I've tried every single remedy out there. Every cream and ointment the derm prescribed. Finally; I stood my ground and needed a change; it was affecting my everyday life terribly. I've been on the methotrexate 15mg and folic acid 1mg for about two months now and my elbows, hands, feet are clear, my elbows and scalp have decreased dramatically! I have absolutely no side effects which was my biggest fear! Life is good! It's amazing!"

10 / 10
Was this helpful?YesNo
70 Report
  • dw-ma...
  • September 4, 2011

For Psoriasis "I have had psorisis all my life (45 yrs). I have been a methotrexate user for 12 years. Before I started using methotrexate I was covered about 90%. Today it is about 1%. Over the years along with blood work. I have had 3 liver biopsy. I have had no side effect."

9 / 10
Was this helpful?YesNo
107 Report
  • Franky
  • Taken for 1 to 6 months
  • January 14, 2020

For Psoriatic Arthritis "I've been taking a combo therapy of sulfasalazine and methodextrate for 5 months. Started at 15 mg. Per week and now down to 5mg. Sulfasalazine remained same the same. Each month inflamation markers are lower. When diagnosed, marker was 24 and last visit was 3. The swelling decreased a lot and don't have the level of pain when first started. Side effects are minimal. Tired the day after but nothing too major. Hair thinning. Still able to bodybuild daily. As a matter of fact, after starting methodextrate, I've felt better overall and have been able to pack on more muscle. Overall, good experience"

9 / 10
Was this helpful?YesNo
48 Report
  • Macar...
  • March 6, 2016

For Rheumatoid Arthritis "Been taking Methotrexate for almost 3 years now. Last fall, I felt good enough that I went off it without my Drs knowledge, because it made me feel pretty ill for a day or so after. What a mistake! I started taking it again about 2 months ago, and although it still makes me sick, it sure beats the pain I`m in without it. (on 25 mg a week, along with Hydroxychloroquin and folic acid)"

7 / 10
Was this helpful?YesNo
76 Report
  • kpalchk
  • Taken for 1 to 2 years
  • January 9, 2014

For Rheumatoid Arthritis "I've had rheumatoid arthritis (RA) for 35 years. I finally found a rheumatologist that was very good. I started on Plaquenil, which was great, but I developed an allergy to it. Switched to methotrexate oral, but had a hard time tolerating the nausea and diarrhea. Switched to injectable methotrexate, and had no nausea, limited diarrhea. It worked moderately well for the RA. Not completely pain free, but could do most things most days. I got cellulitis while on it, so had to go off for about 3 mos. When I went back to it, it didn't seem to work quite as well, and I realized I was experiencing more side effects than I was aware of the first time: thin skin, dermatitis, bruising, bleeding, hair falling out. New rheumatologist (my good one moved) decided to try Arava."

6 / 10
Was this helpful?YesNo
90 Report
  • masey...
  • Taken for less than 1 month
  • July 29, 2014

For Rheumatoid Arthritis "I have been taking methotrexate for two weeks now. Before taking this, I had pain in my hips, knees, ankle and could not walk on the heel of one of my feet. The pain was really bad. I am now walking on my foot again with little pain and do not feel so fatigued and tired, I do feel tired and a bit dizzy for a few days after the medication but not too bad. I am only taking 3 a week at moment, and about to take four, then five and six. Hopefully I wont have to many side affects."

7 / 10
Was this helpful?YesNo
86 Report
  • Anonymous
  • June 19, 2010

For Rheumatoid Arthritis "It definitely helps with the pain and mobility part of rheumatoid arthritis, but I am nauseous usually 2 or three days after I do the shot. I'm also tired a lot and feel weak after I take my weekly shot. Sometimes I don't take it consistently because I don't feel like being sick that week. I do enjoy it when my fingers actually bend though."

7 / 10
Was this helpful?YesNo
111 Report
  • Walki...
  • August 11, 2016

For Rheumatoid Arthritis "Roughly one year now and methotrexate has been working miracles. I started at 10 mg/week and eventually moved up to 12.5 mg/week. From the outset I was tapering off of 10 mg/day of prednisone but could not completely eliminate it until I moved the methotrexate up to 12.5 mg/week. Per doctors recommendation I'm also taking 5,000 mg of vitamin D daily and 1,000 mg of calcium daily (I don't eat much dairy). Side effects: None, except that I sometimes take a short nap after dinner on "methotrexate day" (I take it after lunch so as not to interfere with my pre-dinner martini(s)). Without methotrexate I could barely walk!"

10 / 10
Was this helpful?YesNo
71 Report
  • Puz
  • August 31, 2016

For Rheumatoid Arthritis "I was diagnosed with RA 2 years ago and am grateful that Methotrexate allows me to live a normal life, 20mg once a week, I have a flare every now and then which is managed by a steroid injection. i take 5mg Folic acid everyday to counteract side effects. I am tired on MTX day but generally have not experienced anything negative with the drug. However I take it last thing at night on the day I have to take it, and take it with Milk, I figure if there are any effects I would rather sleep through them, also I don't want to start taking a stomach acid medication so I tried it with milk and it was fine. It's worked for me."

Was this helpful?YesNo
70 Report
  • Anonymous
  • Taken for 6 months to 1 year
  • May 26, 2012

For Psoriasis "It works great! I have had Psoriasis all my adult life and only two things have worked. The first was the original Skin Cap spray from Spain but that disappeared after the U.S. government got involved. This was second. I have been on methrotrexate 2.5mg tablets for 6 months and was fully clear within the first month. No stomach problems and no other side effects. If you suffer from psoriasis, do yourself a favor and find a doctor that will work with you to try it."

10 / 10
Was this helpful?YesNo
94 Report
  • Kari...
  • Taken for 2 to 5 years
  • November 29, 2015

For Rheumatoid Arthritis "I am 23 years old, I was diagnosed with RA at age 21. My pain, swelling & fatigue was so severe, I could barely walk and had to be in a wheelchair during my hospital stay. My Rheum. started me on MTX immediately along with prednisone. At one point I was also taking Enbrel (biologic), but the auto injections were so painful, it outweighed the benefit of the drug and I stopped taking it. I am now only taking prednisone during flare ups and take 25 mgs of MTX every week. The RA already makes me so tired, the added side effects of MTX are next to unbearable. The day after I take the drug, I am so fatigued, I can barely pick my head up. The nausea and vomitting is awful. It is: Would you rather not be able to walk? Or walk and be sick?"

5 / 10
Was this helpful?YesNo
70 Report
  • BooBoos...
  • Taken for 1 to 6 months
  • January 30, 2019

For Rheumatoid Arthritis "I started a low dose of Methotrexate in October and had no changes. In December my Rheum increased my dose and it was like a switch was turned on. Within a week, I felt better than I have in years. I did have a case of "thrush" not long after it was increased and a vaginal yeast infection. I have developed fissures on my tongue but I'm over that - treated - and feeling great. I do get fatigued the day after I take my dose (I take it twice a week) - but that passes quickly. I've also noticed when my doc gives me a shot, it is not as taxing as taking the pills. Lucky for me he says I can just get the shot instead if you want! Having vitamin B12 shots is also the key - I'm doing shots at home - 1/2 dose every two weeks instead of every 4. Life is good."

9 / 10
Was this helpful?YesNo
48 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.