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Rexulti User Reviews & Ratings (Page 5)

Rexulti has an average rating of 6.5 out of 10 from a total of 435 reviews on Drugs.com. 53% of reviewers reported a positive experience, while 27% reported a negative experience.

Reviews for Rexulti

  • Kells
  • Taken for 2 to 5 years
  • May 1, 2020

For Depression "Ok, so I've on on Rexulti for a few years now for depression. This is the best advise I can give someone thinking about taking this Medication. Currently I am on 2mg, I take it for major depression. My Dr started me off on 1mg. It seems like I had side efforts from the drug in the beginning. Dry mouth, weight gain, irritable and fatigue. So I started taking it at night. After about 2 weeks I then switched to morning again. Side efforts went away except for me eating :(. Overall its a good drug if it helps. I would recommend it. DOWNSIDE: do not just stop taking the drug! You most taper down on the medication. You will have effects if you just stop taking it. For example MOODY as heck. Then it takes a few days to build the medicine back up in your body for it to go away."

8 / 10
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  • Doone
  • Taken for 1 to 6 months
  • April 4, 2017

For Major Depressive Disorder "I would give this drug a 10 if it didn't make me gain a little weight. I have had depression my whole life and also have ADD and OCD. It seems to be helping with my depression AND my OCD. I am not taking any other anti-depressants and maybe that is the key. I know it's supposed to be an add on, but my Dr. said I could take it alone. I am also taking Sam e which only helps a bit. I have been taking Rexulti for only about a month. It started working after only a few days and I hope it doesn't stop working. I have taken so many other anti depressants all with side effects or they only worked for a while. I have even had Trans cranial Magnetic Stimulation and it didn't work for me. :("

9 / 10
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56 Report
  • AJ63
  • Taken for 1 to 6 months
  • February 8, 2019

For Major Depressive Disorder "I’ve been taking Rexulti for about 6 months now. I’m presently taking 1 mg/day. This medication has changed my life. I was on an SSRI ( Zoloft then Paxil) for almost 18 years. I had severe breakthrough depression with menopause about 5 years ago and the SSRIs were no longer working. In the past 5 years I have been on numerous medications including atypical antipsychotics, mood stabilizers (Lithium, lamotrigine), Lexapro, Latuda. Nothing was helping and I was so low I was having persistent suicidal thoughts at one point. My psychiatrist started me on Rexulti on a whim. I feel like a new person. More energy and zest for life. I also take Seroquel for sleep which I’m hoping to wean and Adderall 20mg in am. This combo works well for me. It is an expensive drug but you can print an online coupon from Rexulti website for maximum $15 monthly copay with insurance."

10 / 10
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Frequently asked questions

  • No...
  • Taken for less than 1 month
  • June 5, 2016

For Depression "I have been on citalipram\celexa 40mg for years & it just wasn't working anymore....my Psych added the Rexulti .5 mg 3weeks ago and I have never felt better! I take them both @ bedtime. only real side affect is nausea sometimes in the middle of the night. I am so grateful to be able to live again. My doc has given me a month's more samples while they work to try and get my insurance to accept this new med....I hope they do cause my pharmacy quoted me $1000 (not a typo) for my prescription!"

10 / 10
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60 Report
  • Rachel
  • Taken for less than 1 month
  • December 8, 2019

For Major Depressive Disorder "I was on Rexulti (Nov/Dec 2019) for 28 days. The first week I felt great I had more energy, not staying in bed for 16 hours a day. My mood was back to being positive, more outgoing and sarcastically funny. Then I began to feel very short tempered and frustration that got stronger every day. My family was telling me I was acting and talking differently. I at one point sent an email to my brother saying if I ever won the lottery I was going to hire a some to "take care" of a few family members and that he didn't have to worry, he wasn't on my list. I would never talk like this. Another email from me to my psychiatrist earned me a surprise visit from the police to include a complimentary trip to the Crisis Center and then to a hospital for 48 hours. You have to be careful in the the words you use in an attempt to be sarcastically funny - it would have been funny 20 years ago but not in the world we live in today."

1 / 10
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Are you taking this medicine?

  • FLTE
  • July 16, 2016

For Major Depressive Disorder "Have tried this med as an add on to Lexapro twice in past year. Both times I felt an immediate (within 3 days) change/improvement. Started on .5 mg and stopped bc of weight gain. Several months of unrelenting depression strong suicidal thoughts/intentions despite exercise, avoiding alcohol, etc and I knew I had to try it again. Now 1mg and feel quite good. Sleeping pretty much through the night, except when hormonal, but that has been a consistent experience. Overall, I do use less Xanax on this medication. Appetite has increased, but has leveled off. My physical exercise routine has also increased so I would say that I've only gained about 3-4 lbs total, whereas before I had gained about 7-9# previously."

9 / 10
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  • Jano
  • Taken for 1 to 6 months
  • September 17, 2019

For Major Depressive Disorder "I've been anxiety ridden since 7 yrs old with depression. Would not take pysche meds until I finally had a severe breakdown with agoraphobia. Zoloft helped.. but, 5 yrs ago at 56, I needed inpatient care and outpatient programs. I tried over 15 additional meds, nothing worked. Abilify a bit, but too hyper. Rexulti has been great. Gets rid of anxiety fast and depression too. It does stimulate my appetite and I've gained 20lbs."

8 / 10
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  • June
  • Taken for 2 to 5 years
  • March 19, 2019

For Schizophrenia "Go ahead and take this medicine if want to mentally feel better but be prepared to gain 30 pounds and never be able to lose it. Honestly, I don't recommend it at all because the weight gain has ruined my life. Good luck in whatever you decide to do."

5 / 10
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  • Anonymous
  • Taken for 1 to 2 years
  • October 15, 2016

For Major Depressive Disorder "Probably the best antipsychotic I have ever been. I have only responded to Abilify and yet I still had some intense residual depressive, obsessive compulsive, insomnia and anxiety symptoms not allowing me to function well half the time--the side effects of abilify were also too much. My doctor told me about rexulti and how it is a better and more cleaner version of abilify, therefore I agreed to try it. I have now been on it for a year and it has helped me in ways that I am glad that I switched to it. The only issue is that it still causes weight gain and diabetes but these are less severe than on abilify. It is worth dealing with those side effects because now I no longer have insomnia and can function thanks to rexulti."

9 / 10
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57 Report
  • Sophi...
  • Taken for 1 to 6 months
  • February 3, 2020

For Major Depressive Disorder "Rexulti took time to start working and now I feel better than I have for awhile. I've lost my parents and my ESA in the last 6 years. The downside is the weight gain. I've gained 20 lbs in a short period of time. I can't afford to gain weight, I'm already big. I eat the same things, I don't snack. In comparison, before Rexulti I ate more than I do now and didn't gain weight. It's the weight gain that makes it problematic."

6 / 10
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  • Zippy
  • Taken for 1 to 6 months
  • October 14, 2016

For Major Depressive Disorder "I'm taking this for Bipolar 2 with major depressive disorder that has been treatment resistant for over 5 years. Rexulti is the first drug that has ever worked for me. I have tried virtually everything previously with things making me a zombie, worse than I was or simply nothing at all. Rexulti has been a miracle drug for me. It does give me insomnia so I'm going to try to switch to taking it in the morning to see if that helps. I am on a 2 mg dose."

10 / 10
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  • Lauren
  • Taken for 1 to 6 months
  • October 16, 2020

For Major Depressive Disorder "I have Bipolar II with major depressive & Borderline Disorder and I started on .5mg per day for two weeks. I couldn't handle it, brought on a lot side effects. Once doc reduced to .25mg/day, I am feeling very good. The side effects are almost gone. It has helped immensely improved my day to day life with depression which was causing anxiety and other triggers for my mood disorders. I was on lamictal and trileptal before this. I switched entirely to Rexulti 6 weeks ago. Great part of this is quick to help depression. Bad part, tolerance is a bit tricky. Restlessness, digestive, insomnia was horrible when I was on wrong dose. Also, HUNGER is huge. I see why people have gained weight. I don't think it's like SSRIs where it screws w/ your metabolism. It just makes you hungry. Try to get a schedule down for eating and only eat at those times normal amounts of food. This helped me avoid weight gain. Highly recommend."

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  • Jylo
  • Taken for less than 1 month
  • December 11, 2018

For Schizophrenia "Since starting Rexulti a week & a half ago I've been feeling more motivated, I have more energy & I feel less irritable. I'm studying more productively. I haven't been experiencing intrusive thoughts - obviously I can remember what they were, therefore they still enter my mind, but they're not distressing & they don't linger. So, ultimately I feel 'normal' again i.e. without illness or side effects. (I'm still overweight & I still procrastinate, but since beginning this new treatment I have the motivation & energy to transform to the person I want to be)."

8 / 10
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  • Sarah
  • Taken for 1 to 6 months
  • September 7, 2018

For Major Depressive Disorder "I never thought I would feel alive again. I have struggled with major depressive disorder for six years. I’ve been on many medications hoping each time it would be the “magic pill.” When I started Rexulti it took about two weeks for me to feel the positive impact of the medication. I feel present and a part of life again. I can get out of bed and do things and be happy!!!! I am grateful for Rexulti and how it has helped me."

10 / 10
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43 Report
  • Not...
  • Taken for 1 to 2 years
  • March 3, 2019

For Major Depressive Disorder "Rexulti is amazing in two categories: 1) depression and 2) massive weight gain. The weight gain does NOT come off when you stop Rexulti. Four years later, I’m still struggling with the 40 lbs I gained."

5 / 10
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  • Inked...
  • Taken for 1 to 6 months
  • January 3, 2019

For Major Depressive Disorder "I believe this drug has been the best to treat my depression, Bipolar, and PTSD. I went from having suicidal ideations on a daily basis and now I only have intrusive thoughts on occasion. I would recommend trying this drug if you get a chance, I tried Seroquel, Abilify and all they did was make me tired and gain weight. Rexulti has been a great addition to my Lamictal to help balance my Bipolar depression. I give Rexulti a 9/10."

9 / 10
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  • Anonymous
  • Taken for less than 1 month
  • October 7, 2015

For Major Depressive Disorder "I've just started the starter pack of Rexulti I am on day 3. It is replacing Ability in my meds. I feel a lift in the depression, however I am experiencing some agitation and anxiety. I'm hoping this improves. It is affecting my dreaming...they aren't nightmares, just very vivid and strange. I am hopeful for this medicine if we can just get the agitation to cease."

7 / 10
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58 Report
  • Kiara...
  • November 15, 2016

For Major Depressive Disorder "I was put on half a mg for a week, then titrated to 1 mg. Everything was cool until about the 3rd or 4th wk I started feeling overhwelmed and ridiculously tired to where I couldn't keep my eyes open. Then it progrogressed to full blown anxiety in my POV. I never thought it could be rexulti until I finally saw my doc who took me off straight away after seeing how anxious I was. I can hardly deal with my son or life. He sadly has to calm himself as noise and lots of energy around me exascerbate my anxiety. I've been completely off for a day but I'm wondering how long it will be before I'm not anxious. I hope not the 2-4 weeks my doc said. I can't keep living with all this anxiety and tiredness and wanting to cry all the time."

1 / 10
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  • Early...
  • Taken for 6 months to 1 year
  • July 28, 2019

For Major Depressive Disorder "I have bipolar disorder, MDD, and GAD. I tried Abilify as an add on and it made me so tired all the time and I gained weight. We switched to Rexulti and I immediately felt fabulous. I was stable and optimistic! Soon after, I noticed I was eating non stop. It was like an addiction. I struggle with weight as it is. I take Vyvanse for ADHD and it helps curb my appetite a little but the Rexulti still makes me want to eat all the time. Also, I've noticed it makes me really restless and irritable. I think it actually induces hypomania in me. I end up having major outbursts of anger and rage. It's even taken a toll on my marriage. I had to stop. I feel a little depressed but it's better than being out of control."

4 / 10
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  • ram...
  • March 16, 2017

For Major Depressive Disorder "I have been on rexulti for about a year. a lifesaver!! I'm no longer stricken by depression and doomed with sadness and unmotivated. Rexulti has given me life back and I actually want to leave the house and do things. great medication, not for everyone tho. I also did gain 30 pounds. only downside"

9 / 10
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  • Sharl...
  • January 5, 2017

For Major Depressive Disorder "First couple weeks were good but after that had a lot of nervous energy and a lot of waking up thoroughout the night. About a month in a began having intrusive thoughts and had to be hospitalized. They took me off the Rexulti and the intrusive thoughts went away after about two days."

1 / 10
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  • Melan...
  • February 19, 2020

For Depression "I have been on Rexulti for approximately a month now, starting at the 0.5mg dose and now am titrating up to 1mg, I’m an 8 day cycle of alternating between the .5mg to 1mg respectively. This medication was prescribed to me as an add on to Persistent Depressive Disorder ( Dysthymia) by my psychiatrist. I am also prescribed Wellbutrin XL 300mg and Cipralex 20mg ... this cocktail seems to help me enough to get up for work and continue my duties in the home life as a husband and father without considering killing myself . Before I was given Rexulti I was semi suicidal daily so I guess it is helping . It is supposed to mood stabilize and give me an extra boost to get going however I do feel somewhat sedated while on this drug especially the days I take 1mg, which to me is not a bad think I would rather feel ok and sedated vs sad but energetic."

8 / 10
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33 Report
  • Kat
  • Taken for 1 to 6 months
  • April 22, 2021

For Depression "I'm rating this a 10 because I've never had a med work so well on my bipolar depression and the effect was immediate! I can do things again with ease and not steady. I couldn't even get outta bed most days now I'm up early I shower and take care of myself, see friends, do hobbies like painting writing and exercising. I laugh again and it felt like a light switch turned on in my brain. Very thankful for this medication. I take along with lamictal."

10 / 10
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  • Frank...
  • Taken for less than 1 month
  • June 28, 2018

For Major Depressive Disorder "24 years old. 4 yrs of treatment. I've tried Transcranial magnetic stimulation (TMS), etc, MAOIs, SSRIs, SNRIs, DNRI, atypicals...nothing worked. I took Rexulti...boom. I never thought life would ever be this good. God bless the people that found this. Thank you so much. I am going to hang out with my friends and family first time in 4 years."

10 / 10
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  • Coryman
  • Taken for 1 to 6 months
  • August 25, 2018

For Schizophrenia "Rexulti is the first anti-psychotic I've been on with no apparent side effects. It has my schizophrenia under control and has completely gotten rid of my voices. It also helps control my paranoia, psychosis, and helps with my gut-wrenching anxiety so I can get out of my apartment and lead a normal life. I have nothing but good things to say about Rexulti."

10 / 10
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40 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.