Prucalopride Levels and Effects while Breastfeeding
Summary of Use during Lactation
No published experience exists with prucalopride during breastfeeding. However, the manufacturer reports an unpublished study that indicates a relatively low amount of drug in breastmilk. Until more data become available, monitor the breastfed infant for diarrhea.
Drug Levels
Maternal Levels. The manufacturer reports an unpublished study in 8 healthy lactating women who were weaning their infants and given prucalopride 2 mg daily for 4 days. Plasma and milk samples were collected at predose (day 1 and 4), and at 2, 4, 8, 12, and 24 hours after the dose on day 4. The dose to the breastfed infant was estimated to be 1.74 mcg/kg daily, which is about 6% of the weight-adjusted maternal dose.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
