Sertraline - Would it be ok to go from 25mg to 50mg of Zoloft after the first week?

Long story short, I would say yes, it is fine to go from 25 to 50 after a week. Just know that if you are feeling sick, having diarrhea, night sweats, or you feel your anxiety and/or depression is worse, that is a common initial side effect. I can't remember how long it took me to get used to the sertraline the first time I used it, but I do remember being in so much emotional distress that I started to cut myself. Thankfully, my mind is in a much better place than it was when I was 17 (I'm exactly a month from 22 now) and I've learned ways to better cope with the anxiety, so I doubt I would have any urges to cut at this point. I did have to call into work today though, and will probably end up calling in again tomorrow if I have the same reaction from the Sertraline when I take it tonight. If it's anxiety you are taking it for, I would highly suggest asking your doctor for Xanax. It helps block off the chemicals that control fear in your brain. I've been using Xanax to counteract the negative initial side effects of the Sertraline and it's been working pretty well, although I've had to take extra because my anxiety levels are so high right now. Good luck, and keep pushing through! It does get better. When I was on the Zoloft last time I was doing so well that I tried to wean off of it twice because I thought my anxiety was mostly cured. Unfortunately, it doesn't often work like that. I'm very excited to feel better again though!