Zavzpret

Generic name: zavegepant
Dosage form: Nasal spray (10mg/spray)
Drug class: CGRP inhibitors

Medically reviewed by Melisa Puckey, BPharm. Last updated on Aug 23, 2023.

What is Zavzpret?

Zavzpret (zavegepant) is a calcitonin gene-related peptide (CGRP) receptor antagonist nasal spray used to treat acute migraine in adults. Zavzpret can begin relieving pain as early as 15 minutes, and after 2 hours, Zavzpret is significantly better than a placebo at relieving nausea, sensitivity to light (photophobia) or sensitivity to sound (phonophobia).

Zavzpret is not used for preventing migraines.

How does Zavzpret work?

CGRP is a chemical messenger that has a role in causing pain and other symptoms of migraines. Zavzpret is a small molecule CGRP receptor antagonist that works by blocking the CGRP receptors, which reduces migraine pain and other symptoms of migraine, including nausea and sensitivity to light and sound. 

Who should not take Zavzpret?

You should not take this medicine if you are allergic to the active ingredient, zavegepant, or any of the inactive ingredients.  here is a complete list of ingredients at the bottom of the page.

What should I tell my doctor before using Zavzpret?

Tell your healthcare provider about all of your medical conditions, including if you:

 • have kidney problems.

 • have liver problems. 

Pregnancy and Zavzpret 

Tell your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine will harm your unborn baby. 

Breastfeeding and Zavzpret 

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known whether this medicine passes into your breast milk. Talk with your healthcare provider about the best way to feed your baby 

Related/similar drugs

Ubrelvy, ibuprofen, amitriptyline, diclofenac, propranolol, topiramate, celecoxib

How should I take Zavzpret?

• Use this medicine exactly how your healthcare provider tells you to use it.
• Read all the printed instructions your doctor gives you.
• Zavzpret is a nasal spray
• Each dose of this medicine is provided in an individual pack. Use all of the medicine in 1 pack for a complete dose.
• Each Zavzpret only contains 1 time and cannot be reused.
• Do not test or prime the nasal spray before use. 
• Avoid using intranasal decongestants with this medicine.  If you have to use an intranasal decongestant, use it at least 1 hour after using this medicine. 

Dosing information

• The recommended dose is 10 mg given as a single spray in one nostril. 
• Do not use more than 1 spray (10 mg) of Zavzpret nasal spray in a 24-hour period.
•  It is not known if it is safe to use more than 8 sprays (doses) of this medicine in 30 days. 

What are the side effects of Zavzpret?

Common Zavzpret side effects may include:

• unusual taste (dysgeusia)
• feeling sick (nausea)
• nasal discomfort
• vomiting .

Serious Zavzpret side effects include:

Allergic reactions, including hives and swelling of the face, can happen after you use this medicine. Call your healthcare provider or get emergency help right away if you have any of the following symptoms, which may be part of an allergic reaction: 

• swelling of the face, mouth, tongue, or throat 
• trouble breathing

These are not the only possible side effects of this medicine. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800- FDA-1088.

Interactions

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.  

Storage

• Store Zavzpret in the blister package that it comes in.
•  Store at room temperature between 68°F to 77°F (20°C to 25°C).
• Do not freeze.
• Keep this medicine and all medicines out of the reach of children. 

Ingredients

Active ingredients: zavegepant 

Inactive ingredients: dextrose, hydrochloric acid, sodium hydroxide, and succinic acid in water for injection. 

Manufacturer:

Pfizer Labs, Division of Pfizer Inc. New York, NY 10001.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer