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Tbo-filgrastim

Generic name: tbo-filgrastim [ TBO-fil-GRAS-tim ]
Brand name: Granix
Drug class: Colony stimulating factors

Medically reviewed by Drugs.com. Last updated on May 20, 2024.

What is tbo-filgrastim?

Tbo-filgrastim is a man-made form of a protein that stimulates the growth of white blood cells in your body. White blood cells help your body fight against infection.

Tbo-filgrastim is used to reduce the duration of severe neutropenia, a lack of certain white blood cells caused by receiving chemotherapy with certain cancer medications.

Tbo-filgrastim is for use in adults and children who are least 1 month old.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use tbo-filgrastim if you are allergic to filgrastim (Neupogen) or pegfilgrastim (Neulasta).

Tell your doctor if you have ever had:

Using a G-CSF such as tbo-filgrastim can cause your spleen to rupture, which can be fatal. Talk with your doctor if you have concerns about this risk.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How is tbo-filgrastim given?

Use tbo-filgrastim exactly as directed. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Tbo-filgrastim is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use this medicine if you do not understand all the instructions for proper use. Ask your doctor or pharmacist if you have questions.

Prepare your injection only when you are ready to give it. Do not shake the prefilled syringe. Do not use if the medicine has particles in it. Call your pharmacist for new medicine.

The first dose of tbo-filgrastim is usually given within 24 hours after your chemotherapy dose. You will receive daily injections until your blood cell counts return to normal.

You should not inject tbo-filgrastim within 24 hours before your next chemotherapy dose.

Do not stop using this medicine or change your medication schedule without your doctor's advice.

If this medicine accidentally gets on your skin, wash it thoroughly with soap and warm water.

Each prefilled syringe is for one use only. Throw it away after one use, even if there is still medicine left inside.

You will need frequent medical tests to help your doctor determine how long to treat you with tbo-filgrastim.

Store in the refrigerator, do not freeze. Protect from light.

Take the medicine out of the refrigerator and let it reach room temperature for 30 minutes before injecting your dose. Do not leave the medicine out for longer than 5 days.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Bone pain is a common side effect of tbo-filgrastim. Your doctor may recommend you take acetaminophen (Tylenol), ibuprofen (Advil, Motrin) other other medications to relieve pain. Take only the dosage your doctor recommends.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose, or miss an appointment for your injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using tbo-filgrastim?

Avoid injecting tbo-filgrastim into skin that is red, bruised, scarred, tender, or hard.

Avoid getting this medicine in your eyes. If contact does occur, rinse with water.

Tbo-filgrastim side effects

Get emergency medical help if you have signs of an allergic reaction to tbo-filgrastim: hives; wheezing, difficult breathing; fast heart rate, sweating, feeling light-headed; swelling in your face, lips, tongue, or throat.

Capillary leak syndrome is a rare but serious side effect of tbo-filgrastim. Call your doctor right away if you have signs of this condition: stuffy or runny nose followed by weakness or tired feeling, and sudden swelling in your arms, legs and other parts of the body.

Call your doctor at once if you have:

Common tbo-filgrastim side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Dosing information

Usual Adult Dose for Neutropenia Associated with Chemotherapy:

5 mcg/kg via subcutaneous injection once a day
-Duration of therapy: Treatment should continue until the expected neutrophil nadir is
passed and the neutrophil count has recovered to the normal range.

Comments:
-Avoid administration during the period 24 hours before through 24 hours after the administration of cytotoxic chemotherapy.
-Monitor complete blood count (CBC) prior to chemotherapy and then 2 times a week until recovery.

Use: To reduce the duration of severe neutropenia in patients receiving myelosuppressive anticancer drugs associated with a clinically significant incidence of febrile neutropenia

Usual Pediatric Dose for Neutropenia Associated with Chemotherapy:

1 month and older: 5 mcg/kg via subcutaneous injection once a day
-Duration of therapy: Treatment should continue until the expected neutrophil nadir is
passed and the neutrophil count has recovered to the normal range.

Comments:
-Avoid administration during the period 24 hours before through 24 hours after the administration of cytotoxic chemotherapy.
-Monitor CBC prior to chemotherapy and then 2 times a week until recovery.

Use: To reduce the duration of severe neutropenia in patients receiving myelosuppressive anticancer drugs associated with a clinically significant incidence of febrile neutropenia

filgrastim, Neulasta, pegfilgrastim, Zarxio, Neupogen, Granix

What other drugs will affect tbo-filgrastim?

Other drugs may interact with tbo-filgrastim, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Does tbo-filgrastim interact with my other drugs?

Enter other medications to view a detailed interaction report.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use tbo-filgrastim only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.