Cyproheptadine Side Effects
Medically reviewed by Drugs.com. Last updated on Jan 22, 2024.
Applies to cyproheptadine: oral solution, oral tablets.
Side effects include:
Sedation, sleepiness (often transient), dizziness, disturbed coordination, restlessness, excitation.
For Healthcare Professionals
Applies to cyproheptadine: compounding powder, oral syrup, oral tablet.
General
The most commonly reported side effects included drowsiness and somnolence.[Ref]
Nervous system
Common (1% to 10%): Drowsiness, somnolence
Frequency not reported: Convulsions, coordination disturbance, dizziness, faintness, headache, neuritis, paresthesias, sedation/transient sedation, sleepiness/transient sleepiness, tremor, vertigo[Ref]
Some patients who developed drowsiness initially had an apparent improvement in symptoms when they continued taking this drug continuously over the next 3 to 4 days.[Ref]
Psychiatric
Frequency not reported: Aggressive behavior, confusion, euphoria, excitation, hallucinations, hysteria, insomnia, irritability, nervousness, restlessness[Ref]
Gastrointestinal
Frequency not reported: Constipation, diarrhea, dry mouth, epigastric distress, nausea, vomiting[Ref]
Respiratory
Frequency not reported: Chest tightness, dry nose, dry throat, nasal stuffiness, thickened bronchial secretions, wheezing[Ref]
Genitourinary
Frequency not reported: Difficult urination/micturition difficulty, early menses, micturition frequency/urinary frequency, urinary retention[Ref]
Hepatic
Frequency not reported: Cholestasis, hepatitis, jaundice, liver failure, liver function abnormality[Ref]
Dermatologic
Frequency not reported: Allergic rash, excessive perspiration, photosensitivity, urticaria[Ref]
Cardiovascular
Frequency not reported: Extrasystoles, hypotension, palpitation, tachycardia[Ref]
Hematologic
Frequency not reported: Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia[Ref]
Metabolic
Frequency not reported: Anorexia, increased appetite, weight gain[Ref]
Other
Frequency not reported: Chills, fatigue, rigors[Ref]
Hypersensitivity
Frequency not reported: Allergic edema, anaphylactic shock[Ref]
Ocular
Frequency not reported: Blurred vision, diplopia[Ref]
Immunologic
Frequency not reported: Acute labyrinthitis[Ref]
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- Cyproheptadine monograph
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Related treatment guides
References
1. Product Information. Periactin (cyproheptadine). Merck & Co., Inc. 2002;PROD.
2. Cerner Multum, Inc. UK Summary of Product Characteristics.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.