Seldane

Generic name: terfenadine [ ter-FEN-a-deen ]
Drug class: Antihistamines

Medically reviewed by Drugs.com. Last updated on Feb 2, 2024.

What is the most important information I should know about Seldane?

Seldane was withdrawn from the U.S. market in 1998.

Do not take Seldane with any of the following medicines: the antifungal drugs ketoconazole (Nizoral) or itraconazole (Sporanox); the antibiotics erythromycin (E.E.S., E-Mycin, Ery-Tab), clarithromycin (Biaxin), or azithromycin (Zithromax); or the ulcer drug cimetidine (Tagamet, Tagamet HB). A dangerous drug interaction could occur.

What is Seldane?

Seldane was withdrawn from the U.S. market in 1998.

Seldane is an antihistamine. Antihistamines prevent sneezing, runny nose, itching and watering of the eyes, and other allergic symptoms.

Seldane is used to treat allergies, hives (urticaria), and other allergic inflammatory conditions.

Seldane may also be used for purposes other than those listed in this medication guide.

Who should not take Seldane?

You cannot take Seldane if you are taking any of the following medicines:

• the antifungal drugs ketoconazole (Nizoral) or itraconazole (Sporanox);

• the antibiotics erythromycin (E.E.S., E-Mycin, Ery-Tab), clarithromycin (Biaxin), or azithromycin (Zithromax); or

• the ulcer drug cimetidine (Tagamet, Tagamet HB).

A dangerous side effect involving irregular heartbeats could occur if you take Seldane with any of the medicines listed above.

Before taking this medication, tell your doctor if you have

• asthma or another lung disease;

• low potassium levels in your blood;

• urinary retention or an enlarged prostate;

• kidney or liver disease; or

• heart disease, especially an irregular heartbeat.

You may not be able to take Seldane, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Seldane is in the FDA pregnancy category C. This means that it is not known whether Seldane will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is not known whether Seldane passes into breast milk. Do not take Seldane without first talking to your doctor if you are breast-feeding a baby.

Related/similar drugs

prednisone, hydroxyzine, fluticasone nasal, montelukast, promethazine, Zyrtec

How should I take Seldane?

Take Seldane as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass (8 ounces) of water. Do not crush, break, or chew the tablets. Swallow them whole.

Seldane is usually taken twice a day, in the morning and the evening. Never take more of this medication than is directed by your doctor. If your symptoms are not being adequately treated, talk to your doctor.

Store Seldane at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a Seldane overdose include headache, drowsiness, irregular heartbeat, nausea, and vomiting.

What should I avoid?

Use caution when driving, operating machinery, or performing other hazardous activities. Seldane may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking Seldane.

What are the possible side effects of Seldane?

If you experience any of the following serious side effects, stop taking Seldane and call your doctor immediately or seek emergency medical attention.

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• an irregular heartbeat; or

• seizures.

If you experience any of the following less serious side effects, continue taking Seldane and talk to your doctor:

• drowsiness or dizziness;

• headache;

• nervousness;

• nausea, diarrhea, or abdominal discomfort;

• dry mouth; or

• dry skin or itchiness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Seldane?

Never take Seldane with any of the following medications:

• antifungal drugs such as ketoconazole (Nizoral) and itraconazole (Sporanox);

• antibiotics such as erythromycin (E.E.S., E-Mycin, Ery-Tab, others), clarithromycin (Biaxin), and azithromycin (Zithromax); or

• ulcer drugs such as cimetidine (Tagamet, Tagamet HB).

A dangerous side effect involving irregular heartbeats could occur if you take Seldane with any of the medicines listed above.

Before taking this medication, tell your doctor if you are taking any of the following medicines:

• a beta-blocker (heart medication) such as propranolol (Inderal) or metoprolol (Lopressor);

• a monoamine oxidase inhibitor (MAOI) antidepressant such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate);

• a tricyclic antidepressant such as amitriptyline (Elavil), doxepin (Sinequan), or nortriptyline (Pamelor); or

• caffeine, amphetamines, decongestants, or diet pills.

Drugs other than those listed here may also interact with Seldane. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Copyright 1996-2024 Cerner Multum, Inc. Version: 4.04.

Further information

• Your pharmacist has additional information about Seldane written for health professionals that you may read.

What does my medication look like?

Seldane was withdrawn from the U.S. market in 1998.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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