Maprotiline Pregnancy and Breastfeeding Warnings

Brand names: Ludiomil

Maprotiline Pregnancy Warnings

This drug should be used during pregnancy only if clearly needed.

US FDA pregnancy category: B

Comment: A pregnancy registry is available.

Animal studies have failed to reveal evidence of impaired fertility or fetal harm. There are no controlled data in human pregnancy.

To monitor the outcomes of pregnant women exposed to this drug, a pregnancy registry has been established. Physicians are encouraged to register patients and pregnant women are encouraged to register themselves by going to https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/antidepressants.

US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

See references

Maprotiline Breastfeeding Warnings

Caution is recommended.

Excreted into human milk: Yes

Comment: Use of preferred antidepressants should be considered, especially when breastfeeding newborn or premature infants.

After a single dose of 100 mg orally, peak milk levels of 110 mcg/L occurred at approximately 8 hours. Patients at steady state had milk levels corresponding to blood levels.

See references

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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