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Carboprost Pregnancy and Breastfeeding Warnings

Brand names: Hemabate

Medically reviewed by Drugs.com. Last updated on Feb 26, 2024.

Carboprost Pregnancy Warnings

UK: Contraindicated
US: The manufacturer makes no recommendation regarding use during pregnancy.

US FDA pregnancy category: C

Comments:
-There are no clinical data on the effects of this drug on fertility.
-The benzyl alcohol excipient has been associated with a fatal "gasping syndrome" in premature infants.

Carboprost does not appear to directly affect the placental unit; therefore, it is possible that a previable fetus aborted by carboprost could exhibit transient life signs. Studies in animals do not indicate teratogenicity; however, reproductive toxicity has been shown and any dose, which produces increased uterine tone, could put the embryo or fetus at risk.

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

See references

Carboprost Breastfeeding Warnings

The manufacturer makes no recommendation regarding use during lactation.

Excreted into human milk: Data not available
Excreted into animal milk: Data not available

See references

See also

References for pregnancy information

  1. (2001) "Product Information. Hemabate (carboprost)." Pharmacia and Upjohn
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

References for breastfeeding information

  1. (2001) "Product Information. Hemabate (carboprost)." Pharmacia and Upjohn
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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