Study Looks at Alcohol Intake, Mortality Link in Steatotic Liver Disease
By Elana Gotkine HealthDay Reporter
THURSDAY, Dec. 14, 2023 -- For individuals with steatotic liver disease (SLD) at low risk for advanced fibrosis, there is a nonlinear association between alcohol consumption and mortality, with increased risk at or above consumption of 7.4 g/day, according to a research letter published online Dec. 14 in JAMA Network Open.
Yee Hui Yeo, M.D., from Cedars-Sinai Medical Center in Los Angeles, and colleagues examined the dose-dependent association of alcohol use with progression of SLD using a noninvasive method based on data from the U.S. National Health and Nutrition Examination Survey III (1988 to 1994) database, followed through Dec. 31, 2019.
The researchers found that 20.8 percent of the 2,834 individuals with SLD had intermediate or high risk of advanced fibrosis, with male predominance and higher prevalence of metabolic disorders. Individuals at intermediate or high risk of advanced fibrosis had a mortality rate of 4,342 per 100,000 persons during 66,299 person years of follow-up, compared with 1,099 per 100,000 persons in the low-risk group. A nonlinear association between alcohol consumption and mortality was seen in the low-risk group after adjustment for demographic characteristics and metabolic variables. At a 7.4-g daily intake, mortality risk exceeded an adjusted hazard ratio of 1.00. In the intermediate- or high-risk groups, a linear association was observed between daily alcohol consumption and increased mortality risk.
"The finding aligns with previous research indicating higher risk of fibrosis progression among moderate drinkers," the authors write. "Individuals with SLD should be advised to maintain regular health monitoring and lifestyle management."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted December 2023
Read this next
Small but Important Differences Seen Between Rosuvastatin, Atorvastatin
WEDNESDAY, Oct. 30, 2024 -- There are small but important differences in risk for some clinical outcomes associated with rosuvastatin and atorvastatin, according to a study...
Referral to Hepatology Low With Excessive Alcohol Use, High FIB-4
MONDAY, Oct. 7, 2024 -- Only 37 percent of patients with excessive alcohol use (EAU) and a high fibrosis-4 index (FIB-4) are referred to hepatology, according to a study published...
People With Chronic Liver Disease Face More Barriers to Health Care
THURSDAY, Aug. 29, 2024 -- People with chronic liver disease (CLD) have a higher likelihood of barriers to health care, according to a study recently published in Gastro Hep...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.