Sincalide

Generic name: sincalide [ SIN-ka-lide ]
Brand name: Kinevac
Dosage form: injectable powder for injection (5 mcg)
Drug class: Miscellaneous uncategorized agents

Medically reviewed by Drugs.com on Jan 29, 2024. Written by Cerner Multum.

What is sincalide?

Sincalide is used to help diagnose disorders of the gallbladder or pancreas.

Sincalide is also used to speed up digestion of barium, a contrast agent, given in preparation for x-ray examination of the intestines.

Sincalide may also be used for purposes not listed in this medication guide.

Sincalide side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Sincalide may cause serious side effects. Call your doctor at once if you have:

• severe nausea, vomiting, diarrhea, or stomach cramps; or

• a light-headed feeling, like you might pass out.

Common side effects of sincalide may include:

• stomach pain or discomfort; or

• nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not receive sincalide if you have a blockage in your intestines.

Tell your doctor if you are pregnant. Receiving sincalide during pregnancy may result in a miscarriage or premature labor.

Before taking this medicine

You should not be treated with sincalide if you are allergic to it, or if you have a blockage in your intestines.

Tell your doctor if you have ever had:

• gallstones.

Tell your doctor if you are pregnant. Receiving this medicine during pregnancy may result in a miscarriage or premature labor.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How is sincalide given?

Sincalide is given as an infusion into a vein.

A healthcare provider will give you this injection as part of your medical test or x-ray.

Sincalide dosing information

Usual Adult Dose for Barium Meal Transit:

To accelerate the transit time of a barium meal through the small bowel, sincalide should be administered after the barium meal is beyond the proximal jejunum (sincalide, like cholecystokinin, may cause pyloric contraction). The recommended dose is 0.04 mcg per kg IV over a 30- to 60-second interval. If satisfactory transit of the barium meal has not occurred in 30 minutes, a second dose may be administered.

To reduce intestinal side effects, a 30-minute IV infusion 0.12 mcg per kg diluted to approximately 100 mL with sodium chloride may be administered.

Usual Adult Dose for Pancreatic Secretion:

To test pancreatic function: 0.25 units per kg IV over a 60-mlnute period.

Thirty minutes after the initiation of the infusion, a separate IV infusion at a total dose of 0.02 mcg per kg is administered over a 30-minute interval (for example, the total dose for a 70 kg patient is 1.4 mcg of sincalide; therefore, dilute 1.4 mL of reconstituted solution to 30 mL with sodium chloride Injection and administer at a rate of 1 mL per minute).

Usual Adult Dose for Gallbladder Contraction:

Initial dose: IV: 0.02 mcg/kg over 30 to 60 minutes

If satisfactory contraction of the gallbladder does not occur in 15 minutes, a second dose, 0.04 mcg/kg IV may be administered.

To reduce intestinal side effects, an intravenous infusion may be prepared at a dose of 0.12 mcg/kg in 100 mL of sodium chloride Injection and given at a rate of 2 mL per minute. Alternatively, an intramuscular dose of 0.1 mcg/kg may be given.

When sincalide is used in cholecystography, roentgenograms are usually taken at five-minute Intervals after the injection. For visualization of the cystic duct, it may be necessary to take roentgenograms at one-minute intervals during the first five minutes after the injection.

What happens if I miss a dose?

Sincalide is used as a single dose and does not have a daily dosing schedule.

What happens if I overdose?

Since sincalide is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid before or after receiving sincalide?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect sincalide?

Other drugs may affect sincalide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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