Hydrochlorothiazide and captopril

Generic name: hydrochlorothiazide and captopril [ hye-droe-klor-oh-THY-a-zide-and-KAP-toe-pril ]
Brand names: Capozide 25/15, Capozide 25/25, Capozide 50/15, Capozide 50/25
Dosage form: oral tablet (25 mg-15 mg; 25 mg-25 mg; 50 mg-15 mg; 50 mg-25 mg)
Drug class: ACE inhibitors with thiazides

Medically reviewed by Drugs.com on Feb 27, 2024. Written by Cerner Multum.

What is hydrochlorothiazide and captopril?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Captopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Captopril lowers blood pressure and also relieves symptoms of fluid retention.

Hydrochlorothiazide and captopril is a combination medicine used to treat hypertension (high blood pressure).

Hydrochlorothiazide and captopril may also be used for purposes not listed in this medication guide.

Hydrochlorothiazide and captopril side effects

Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Hydrochlorothiazide and captopril may cause serious side effects. Call your doctor at once if you have:

• a light-headed feeling, like you might pass out;

• eye pain, vision problems;

• little or no urinating;

• chest pain, pounding heartbeats or fluttering in your chest;

• swelling, weight gain, shortness of breath;

• pale skin, easy bruising or bleeding;

• sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, trouble swallowing;

• high potassium--nausea, slow or unusual heart rate, weakness, loss of movement;

• low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;

• low levels of sodium--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; or

• severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects of hydrochlorothiazide and captopril may include:

• cough;

• mild itching or rash;

• joint pain;

• numbness in your hands or feet;

• decreased sense of taste; or

• flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Do not use if you are pregnant. If you become pregnant, stop taking hydrochlorothiazide and captopril and tell your doctor right away.

You should not use this medicine if you are unable to urinate, or if you are allergic to sulfa drugs or any ACE inhibitor.

If you have diabetes, do not use hydrochlorothiazide and captopril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo).

Before taking this medicine

You should not use this medication if you are allergic to hydrochlorothiazide or captopril, or if:

• you are unable to urinate;

• you are allergic to sulfa drugs; or

• you are allergic to any other ACE inhibitor, such as benazepril, enalapril, fosinopril, lisinopril, quinapril, ramipril, trandolapril, and others.

If you have diabetes, do not use hydrochlorothiazide and captopril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo).

You may also need to avoid taking hydrochlorothiazide and captopril with aliskiren if you have kidney disease.

To make sure hydrochlorothiazide and captopril is safe for you, tell your doctor if you have:

• kidney disease (or if you are on dialysis);

• cirrhosis or other liver disease;

• glaucoma;

• congestive heart failure;

• gout;

• lupus;

• diabetes; or

• an allergy to sulfa drugs or penicillin.

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Captopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

Hydrochlorothiazide and captopril can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

How should I take hydrochlorothiazide and captopril?

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use hydrochlorothiazide and captopril in larger or smaller amounts or for longer than recommended.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and captopril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.

Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated. Visit your doctor regularly.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and captopril. You may need to stop using the medicine for a short time.

Store at room temperature away from moisture, heat, and light.

Hydrochlorothiazide and captopril dosing information

Usual Adult Dose for Hypertension:

Initial dose: Captopril 25 mg-Hydrochlorothiazide 15 mg orally once a day 1 hour before meals
Maximum dose: Captopril 150 mg-Hydrochlorothiazide 50 mg per day

Comments: The full effect of a given dose may not be attained for 6 to 8 weeks; dose adjustments should be made at 6 week intervals, unless the clinical situation demands more rapid adjustment.

Use: Treatment of hypertension as initial therapy or substituted for previously titrated doses of the individual components.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking hydrochlorothiazide and captopril?

Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and captopril.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and captopril, unless your doctor has told you to.

What other drugs will affect hydrochlorothiazide and captopril?

Tell your doctor about all your current medicines and any you start or stop using, especially:

• lithium; or

• other diuretics (water pills) or blood pressure medications.

This list is not complete. Other drugs may interact with hydrochlorothiazide and captopril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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