Gadobutrol

Generic name: gadobutrol [ GAD-oh-BUE-trol ]
Brand name: Gadavist
Dosage form: intravenous solution (604.72 mg/mL)
Drug class: Magnetic resonance imaging contrast media

Medically reviewed by Drugs.com on Apr 30, 2024. Written by Cerner Multum.

What is gadobutrol?

Gadobutrol is a contrast agent that has magnetic properties. It is used in combination with magnetic resonance imaging (MRI) or magnetic resonance angiography (MRA) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly.

Gadobutrol is used to help diagnose certain disorders of the brain and spine (central nervous system), the blood vessels of the kidneys, and the heart. Gadobutrol is also used in adults to help diagnose breast cancer and to evaluate how well blood flows through your heart.

Gadobutrol may also be used for purposes not listed in this medication guide.

Gadobutrol side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Some side effects of gadobutrol may occur up to several days after injection.

Gadobutrol can cause a life-threatening condition in people with advanced kidney disease. Call your doctor right away if you have any symptoms of this condition, such as:

• burning, itching, swelling, scaling, and tightening or hardening of your skin;

• skin redness or discoloration;

• muscle weakness;

• joint stiffness in your arms, hands, legs, or feet;

• pain; or

• tiredness, trouble moving.

Gadobutrol may cause serious side effects. Call your doctor at once if you have:

• kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;

• a seizure (convulsions); or

• chest pain or pressure, pain spreading to your jaw or shoulder.

Common side effects of gadobutrol may include:

• pain, burning, irritation, or skin changes where the injection was given;

• headache;

• unusual or unpleasant taste in your mouth;

• nausea; or

• dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

glucagon, mannitol, Lexiscan, Ceretec, arginine, Magnevist, metyrapone

Warnings

Gadobutrol can cause a life-threatening condition in people with advanced kidney disease. Before receiving gadobutrol, tell your doctor if you have kidney disease or if you are on dialysis. You may not be able to receive gadobutrol. Also tell your doctor if you have recently received any contrast agents similar to gadobutrol.

Before taking this medicine

Gadobutrol can cause a life-threatening condition in people with advanced kidney disease. Ask your doctor about your individual risk.

Gadobutrol can stay in your body for months or years after you receive gadobutrol. It is not known whether this could cause any health problems in people whose kidneys work properly. Tell your doctor if you have had repeated scans with a contrast agent, and provide the date of your last scan.

You should not receive gadobutrol if you are allergic to it.

Tell your doctor if you have ever had:

• any type of reaction to a contrast agent;

• diabetes;

• high blood pressure;

• asthma, hay fever, food or drug allergies; or

• liver or kidney disease.

Tell your doctor if you are pregnant or breastfeeding.

How is gadobutrol given?

Gadobutrol is given as an infusion into a vein. A healthcare provider will give you this injection.

You will be watched for a short time to make sure you do not have an allergic reaction.

Gadobutrol dosing information

Usual Adult Dose for CNS Magnetic Resonance Imaging:

0.1 mL/kg body weight (0.1 mmol/kg) IV bolus injection
Comments: Administer manually or by power injector at a flow rate of approximately 2 mL/second. Refer to manufacturer product information to determine volume to be administered.

Use: Indicated for use with MRI to detect and visualize areas with disrupted blood brain barrier (BBB) and/or abnormal vascularity of the central nervous system.

Usual Adult Dose for Diagnostic:

0.1 mL/kg body weight (0.1 mmol/kg) IV bolus injection
Comments: Administer manually or by power injector at a flow rate of approximately 2 mL/second. Refer to manufacturer product information to determine volume to be administered.

Use: Indicated for use with MRI to assess the presence and extent of malignant breast disease.

Usual Pediatric Dose for CNS Magnetic Resonance Imaging:

0.1 mL/kg body weight (0.1 mmol/kg) IV bolus injection
Comments: Administer manually or by power injector at a flow rate of approximately 2 mL/second. Refer to manufacturer product information to determine volume to be administered.

Use:
-Indicated for use with MRI to detect and visualize areas with disrupted blood brain barrier (BBB) and/or abnormal vascularity of the central nervous system.

What happens if I miss a dose?

In a medical setting you are not likely to miss a dose.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid after receiving gadobutrol?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect gadobutrol?

Other drugs may affect gadobutrol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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