What types of MS does Ocrevus treat?
Ocrevus (ocrelizumab) is the first treatment approved for primary progressive multiple sclerosis (PPMS). It is also approved for the more common relapsing forms of multiple sclerosis.
What is Multiple Sclerosis?
Multiple sclerosis (MS) is a chronic disease that occurs when the immune system abnormally attacks the insulation and support around nerve cells (myelin sheath) in the brain, spinal cord and optic nerves, causing inflammation and consequent damage. Symptoms include muscle weakness, fatigue and difficulty seeing, and may eventually lead to disability.
- Relapsing forms of MS (RMS) include people with relapsing-remitting MS (RRMS) and people with secondary progressive MS (SPMS) who continue to experience relapses. RRMS is the most common form of the disease and is characterized by episodes of new or worsening signs or relapses followed by periods of recovery. Most people with RRMS will eventually transition to SPMS, in which they experience steadily worsening disability over time.
- Primary progressive MS (PPMS) is a debilitating form of the disease marked by steadily worsening symptoms but typically without distinct relapses or periods of remission. Approximately 15 percent of people with MS are diagnosed with the primary progressive form of the disease.
What is Ocrevus?
Ocrevus is a humanized monoclonal antibody designed to selectively target CD20-positive B cells, thought to be a key contributor to myelin damage. It works by binding to the CD20 cell surface proteins expressed on certain B cells so that important functions of the immune system may be preserved.
In the Phase III ORATORIO PPMS study, Ocrevus was shown to significantly slow disability progression in patients with primary progressive multiple sclerosis, and reduce signs of disease activity in the brain (MRI lesions) compared with placebo with a median follow-up of three years.
Ocrevus is administered by intravenous infusion every six months. The initial dose is given as two infusions given two weeks apart.
Side effects include infusion reactions and upper respiratory tract infections.
Related Questions
References
- Genentech Press Release: FDA Approves Genentech’s OCREVUS™ (Ocrelizumab) For Relapsing and Primary Progressive Forms of Multiple Sclerosis Available at https://www.gene.com/media/press-releases/14657/2017-03-28/fda-approves-genentechs-ocrevus-ocrelizu [Accessed February 16, 2021]
- Food and Drug Administration. OCREVUS® Product Label. Available at https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/761053s022lbl.pdf [Accessed February 16, 2021]
Read next
Related medical questions
- How does Ocrevus work for MS?
- What are the new drugs used for multiple sclerosis (MS)?
- Ocrevus vs Aubagio: How do they compare for MS?
- How long can you live with multiple sclerosis?
- What are the early warning signs of Multiple Sclerosis?
- How do you test for multiple sclerosis?
- What are the early signs of multiple sclerosis?
- Prednisone: What are 12 Things You Should Know?
- Prednisone vs Prednisolone - What's the difference?
- What are 8 key Kesimpta side effects to watch out for?
- Who is the actress in the Kesimpta commercial?
- Is Tecfidera an immunosuppressant?
- How do Vumerity and Tecfidera compare for multiple sclerosis (MS)?
- Can I stop taking Tecfidera? What happens if I do?
- What causes flushing with Tecfidera?
- Can you drink alcohol while taking Tecfidera?
- Where and how should Copaxone be injected?
- Does Tysabri suppress the immune system?
- How effective is Mavenclad for MS?
- How long can you take Tysabri for?
- Gilenya vs Tecfidera. How do they compare?
- How long can you take Tecfidera?
- What happens when you stop taking Gilenya?
- How quickly does Mavenclad work?
- Does Aubagio suppress the immune system?
- Is Mavenclad a chemotherapy drug?
- Can Gilenya cause weight gain?
- Can Tecfidera cause stomach damage?
- Can Gilenya cause high blood pressure?
- Does Aubagio cause weight gain or loss?
Drug information
- Ocrevus Information for Consumers
- Ocrevus prescribing info & package insert (for Health Professionals)
- Side Effects of Ocrevus (detailed)
Related support groups
- Ocrevus (12 questions, 12 members)
- Multiple Sclerosis (88 questions, 549 members)