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How to transition to Invega Trinza from Invega Sustenna ?

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 26, 2023.

Official answer

by Drugs.com

Before people transition to Invega Trinza, they need to have been administered Invega Sustenna for at least 4 months and tolerated it well. For a seamless transition, it is recommended that the last two doses of Invega Sustenna are the same dosage strength before starting Invega Trinza. Start Invega Trinza up to 7 days before, on, or 7 days after the day the next 1-month Invega Sustenna dose was due. Your doctor will choose a starting dose of Invega Trinza that is 3.5-fold higher than the last Invega Sustenna dose, for example:

  • If the last dose of Invega Sustenna was 78 mg then Invega Trinza should be initiated at 273 mg
  • If the last dose of Invega Sustenna was 117 mg then Invega Trinza should be initiated at 410 mg
  • If the last dose of Invega Sustenna was 156 mg then Invega Trinza should be initiated at 546 mg
  • If the last dose of Invega Sustenna was 234 mg then Invega Trinza should be initiated at 819 mg.
References
  • Invega Sustenna (paliperidone palmitate). Updated 08/2021. Janssen Pharmaceuticals, Inc. https://www.drugs.com/pro/invega-sustenna.html
  • Invega Trinza (paliperidone palmitate). Updated 08/2021. Janssen Pharmaceuticals, Inc. https://www.drugs.com/pro/invega-trinza.html#s-34069-5

Read next

You should avoid the use of alcohol while being treated with Invega Sustenna (paliperidone palmitate). Combining alcohol with Invega Sustenna can increase side effects like dizziness, drowsiness, and trouble concentrating. This may also affect your ability to make decisions, think clearly, or react quickly. Continue reading

The difference between Invega Sustenna, Invega Trinza, and Invega Hayfera is the length of time they last in the body. Invega Sustenna lasts for 1 month, Invega Trinza lasts for 3 months, and Invega Hayfera lasts for 6 months and only needs to be given twice a year. Before transitioning to Invega Hayfera, patients must be adequately treated with Invega Sustenna for at least 4 months, or Invega Trinza for at least one 3-month injection cycle. Continue reading

Invega Sustenna is administered by a healthcare professional into either the deltoid muscle of the arm or the gluteal muscle of the buttocks once a month following an initial loading dose period. Invega Sustenna is usually started with a dose of 234mg given IM, followed by 156mg IM one week later. Thereafter, monthly injections of 39mg to 234mg IM are given, depending on the condition being treated, individual dosage requirements, and how well the person tolerates Invega Sustenna. Continue reading

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