Drug Interaction Report
62 potential interactions and/or warnings found for the following 15 drugs:
- carbamazepine
- ciprofloxacin
- clonazepam
- gabapentin
- guanfacine
- ketamine
- lorazepam
- omeprazole
- ondansetron
- oxybutynin
- risperidone
- Benadryl (diphenhydramine)
- Macrobid (nitrofurantoin)
- MiraLAX (polyethylene glycol 3350)
- Tylenol (acetaminophen)
Interactions between your drugs
carBAMazepine risperiDONE
Applies to: carbamazepine, risperidone
ADJUST DOSE: Coadministration with potent inducers of CYP450 3A4 and/or P-glycoprotein (P-gp) may decrease the plasma concentrations of risperidone and its active metabolite, 9-hydroxyrisperidone. Both risperidone and 9-hydroxyrisperidone are substrates of the CYP450 3A4 isoenzyme and P-gp efflux transporter. Since 9-hydroxyrisperidone has similar pharmacological activity as the parent drug, the clinical effect of risperidone results from the combined plasma concentrations of both entities. When oral risperidone 3 mg twice daily was coadministered with the potent CYP450 3A4 and P-gp inducer carbamazepine at an average dosage of 573 mg/day (+/-168 mg/day) in study patients, steady-state peak plasma concentration (Cmax) and systemic exposure (AUC) values for the total active moiety (risperidone plus 9-hydroxyrisperidone) decreased by 45% and 49%, respectively. Plasma concentrations of carbamazepine did not appear to be affected. Rifampin, another potent 3A4 and P-gp inducer, decreased the Cmax and AUC of the total active moiety by 41% and 45%, respectively, following a single 1 mg oral dose of risperidone. The interaction was suspected in a case report of two patients treated with risperidone who developed parkinsonian symptoms several weeks following the discontinuation of carbamazepine. The symptoms resolved completely in both cases within a week after risperidone dosage was reduced. In addition, when two or more medications with similar adverse effect profiles are given concurrently, the likelihood of experiencing these adverse reactions may be increased. For example, coadministration with other agents that can prolong the QT interval (e.g., apalutamide, encorafenib, enzalutamide) may result in additive effects and an increased risk of ventricular arrhythmias like torsade de pointes.
MANAGEMENT: When risperidone is administered orally, some authorities recommend increasing (up to double) the usual dosage gradually (e.g., over 1 to 2 weeks) following the addition of a potent CYP450 3A4/P-gp inducer. For extended-release injectable formulations of risperidone, patients should be closely monitored for the first 4 to 8 weeks after starting treatment with a potent CYP450 3A4/P-gp inducer. A dosage increase or supplemental oral risperidone therapy may be required in some cases. Changes in efficacy and safety should be carefully monitored with any dosage adjustment. If the CYP450 3A4 inducer also carries a risk of prolonging the QT interval, then obtaining more frequent electrocardiograms (ECGs) to monitor the QT interval may be advisable. Patients should be counseled to seek immediate medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, syncope, palpitations, irregular heartbeat, and/or shortness of breath. Upon discontinuation of the inducer, risperidone dosage should be reassessed and readjusted accordingly for the anticipated increase in plasma concentrations of risperidone and 9-hydroxyrisperidone. The prescribing information for individual risperidone products should be consulted for specific recommendations regarding concomitant use with potent CYP450 3A4 inducers.
References
- (2001) "Product Information. Risperdal (risperidone)." Janssen Pharmaceuticals
- Spina E, Avenoso A, Facciola G, Salemi M, Scordo MG, Giacobello T, Madia AG, Perucca E (2000) "Plasma concentrations of risperidone and 9-hydroxyrisperidone: Effect of comedication with carbamazepine or valproate." Ther Drug Monit, 22, p. 481-5
- Spina E, Scordo MG, Avenoso A, Perucca E (2001) "Adverse drug interaction between risperidone and carbamazepine in a patient with chronic schizophrenia and deficient CYP2D6 activity." J Clin Psychopharmacol, 21, p. 108-9
- (2022) "Product Information. RisperDAL (risperiDONE)." Janssen Pharmaceuticals
- (2022) "Product Information. Perseris (risperiDONE)." Indivior Inc.
- (2021) "Product Information. RisperDAL Consta (risperiDONE)." Janssen Pharmaceuticals
- (2022) "Product Information. Teva-Risperidone (risperidone)." Teva Canada Limited
- (2021) "Product Information. Perseris (risperidone)." HLS Therapeutics Inc
- (2020) "Product Information. Risperdal Consta (risperidone)." Janssen Inc
- (2022) "Product Information. Rixadone (riSPERIDONe)." Alphapharm Pty Ltd
- (2020) "Product Information. Risperdal Consta (riSPERIDONe)." Janssen-Cilag Pty Ltd
- (2023) "Product Information. Risperidone (risperidone)." Krka UK Ltd
- (2022) "Product Information. Okedi (risperidone)." ROVI Biotech Ltd
- (2022) "Product Information. Risperdal Consta (risperidone)." Janssen-Cilag Ltd
ketamine guanFACINE
Applies to: ketamine, guanfacine
MONITOR CLOSELY: Coadministration of ketamine with other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. In addition, opioid analgesics, barbiturates, and benzodiazepines may prolong the time to complete recovery from anesthesia.
MANAGEMENT: During concomitant use of ketamine with other CNS depressants, including alcohol, close monitoring of neurologic status and respiratory parameters, including respiratory rate and pulse oximetry, is recommended. Dosage adjustments should be considered according to the patient's clinical situation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- (2009) "Product Information. Ketalar (ketamine)." JHP Pharmaceuticals
ketamine gabapentin
Applies to: ketamine, gabapentin
MONITOR CLOSELY: Coadministration of ketamine with other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. In addition, opioid analgesics, barbiturates, and benzodiazepines may prolong the time to complete recovery from anesthesia.
MANAGEMENT: During concomitant use of ketamine with other CNS depressants, including alcohol, close monitoring of neurologic status and respiratory parameters, including respiratory rate and pulse oximetry, is recommended. Dosage adjustments should be considered according to the patient's clinical situation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- (2009) "Product Information. Ketalar (ketamine)." JHP Pharmaceuticals
carBAMazepine ketamine
Applies to: carbamazepine, ketamine
MONITOR CLOSELY: Coadministration of ketamine with other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. In addition, opioid analgesics, barbiturates, and benzodiazepines may prolong the time to complete recovery from anesthesia.
MANAGEMENT: During concomitant use of ketamine with other CNS depressants, including alcohol, close monitoring of neurologic status and respiratory parameters, including respiratory rate and pulse oximetry, is recommended. Dosage adjustments should be considered according to the patient's clinical situation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- (2009) "Product Information. Ketalar (ketamine)." JHP Pharmaceuticals
LORazepam ketamine
Applies to: lorazepam, ketamine
MONITOR CLOSELY: Coadministration of ketamine with other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. In addition, opioid analgesics, barbiturates, and benzodiazepines may prolong the time to complete recovery from anesthesia.
MANAGEMENT: During concomitant use of ketamine with other CNS depressants, including alcohol, close monitoring of neurologic status and respiratory parameters, including respiratory rate and pulse oximetry, is recommended. Dosage adjustments should be considered according to the patient's clinical situation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- (2009) "Product Information. Ketalar (ketamine)." JHP Pharmaceuticals
clonazePAM ketamine
Applies to: clonazepam, ketamine
MONITOR CLOSELY: Coadministration of ketamine with other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. In addition, opioid analgesics, barbiturates, and benzodiazepines may prolong the time to complete recovery from anesthesia.
MANAGEMENT: During concomitant use of ketamine with other CNS depressants, including alcohol, close monitoring of neurologic status and respiratory parameters, including respiratory rate and pulse oximetry, is recommended. Dosage adjustments should be considered according to the patient's clinical situation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- (2009) "Product Information. Ketalar (ketamine)." JHP Pharmaceuticals
diphenhydrAMINE ketamine
Applies to: Benadryl (diphenhydramine), ketamine
MONITOR CLOSELY: Coadministration of ketamine with other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. In addition, opioid analgesics, barbiturates, and benzodiazepines may prolong the time to complete recovery from anesthesia.
MANAGEMENT: During concomitant use of ketamine with other CNS depressants, including alcohol, close monitoring of neurologic status and respiratory parameters, including respiratory rate and pulse oximetry, is recommended. Dosage adjustments should be considered according to the patient's clinical situation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- (2009) "Product Information. Ketalar (ketamine)." JHP Pharmaceuticals
ketamine risperiDONE
Applies to: ketamine, risperidone
MONITOR CLOSELY: Coadministration of ketamine with other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. In addition, opioid analgesics, barbiturates, and benzodiazepines may prolong the time to complete recovery from anesthesia.
MANAGEMENT: During concomitant use of ketamine with other CNS depressants, including alcohol, close monitoring of neurologic status and respiratory parameters, including respiratory rate and pulse oximetry, is recommended. Dosage adjustments should be considered according to the patient's clinical situation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- (2009) "Product Information. Ketalar (ketamine)." JHP Pharmaceuticals
carBAMazepine guanFACINE
Applies to: carbamazepine, guanfacine
ADJUST DOSE: Coadministration with inducers of CYP450 3A4 may significantly decrease the plasma concentrations of guanfacine, which is primarily metabolized by the isoenzyme. Rifampin, a potent CYP450 3A4 inducer, has been reported to decrease guanfacine peak plasma concentration (Cmax) and systemic exposure (AUC) by 54% and 70%, respectively. A computer simulation suggests that efavirenz, a moderate CYP450 3A4 inducer, would reduce guanfacine Cmax and AUC by a similar magnitude.
MANAGEMENT: Close monitoring and dosage adjustment should be considered when guanfacine is administered with potent and moderate CYP450 3A4 inducers. For extended-release guanfacine, some manufacturers recommend increasing the dosage up to double the recommended level when initiating therapy in patients who are already receiving a CYP450 3A4 inducer. Further dosage adjustments may be required based on patient tolerance and response. If a CYP450 3A4 inducer is added to existing guanfacine therapy, the guanfacine dosage may be increased up to double the recommended level over 1 to 2 weeks. The dosage should be decreased to the recommended level over 1 to 2 weeks following discontinuation of the CYP450 3A4 inducer.
References
- Kiechel JR, Lavene D, Guerret M, Comoy E, Godin M, Fillastre JP (1983) "Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure." Eur J Clin Pharmacol, 25, p. 463-6
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2009) "Product Information. Intuniv (guanfacine)." Shire US Inc
ciprofloxacin guanFACINE
Applies to: ciprofloxacin, guanfacine
ADJUST DOSE: Coadministration with inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of guanfacine, which is primarily metabolized by the isoenzyme. The risk of adverse reactions such as hypotension, bradycardia, and sedation may increase. Ketoconazole, a potent CYP450 3A4 inhibitor, has been reported to increase guanfacine peak plasma concentration (Cmax) and systemic exposure (AUC) by 2- and 3-fold, respectively. A computer simulation suggests that fluconazole, a moderate CYP450 3A4 inhibitor, would increase guanfacine Cmax and AUC by about 1.5- and 2-fold, respectively.
MANAGEMENT: Caution and dosage adjustment are advised when guanfacine is administered with potent and moderate CYP450 3A4 inhibitors. For extended-release guanfacine, the manufacturers recommend reducing the dosage to half the recommended level during concomitant use . Further dosage adjustments may be required based on patient tolerance and response. The dosage should be increased to the recommended level following discontinuation of the CYP450 3A4 inhibitor.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2009) "Product Information. Intuniv (guanfacine)." Shire US Inc
No other interactions were found between your selected drugs. However, this does not necessarily mean no other interactions exist. Always consult your healthcare provider.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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