Vonjo Dosage
Generic name: Pacritinib 100mg
Dosage form: capsule
Drug class: Multikinase inhibitors
Medically reviewed by Drugs.com. Last updated on Aug 23, 2023.
Recommended Dosage
The recommended dosage of VONJO is 200 mg orally twice daily. VONJO may be taken with or without food.
Swallow capsules whole. Do not open, break, or chew capsules.
Patients who are on treatment with other kinase inhibitors before the initiation of VONJO must taper or discontinue according to the prescribing information for that drug.
Monitoring for Safety
Perform a complete blood count (CBC; including white blood cell count differential and platelet count), coagulation testing (prothrombin time, partial thromboplastin time, thrombin time, and international normalized ratio) and a baseline electrocardiogram (ECG), prior to starting VONJO, and monitor as clinically indicated while the patient is on treatment.
Missed Dose
If a dose of VONJO is missed, the patient should take the next prescribed dose at its scheduled time. Extra capsules should not be taken to make up for the missed dose.
Dose Interruption for Planned Surgical Procedures or Other Interventions
Discontinue VONJO 7 days prior to elective surgery or invasive procedures because of the risk of hemorrhage and restart only after hemostasis is assured.
Dose Modification for Adverse Reactions
Dose modifications for diarrhea, thrombocytopenia, hemorrhage, and prolonged QT interval are described in Table 1, Table 2, Table 3, and Table 4 respectively. See Warning and Precautions (5.1, 5.2, 5.3, and 5.4) for additional risk minimization recommendations.
Dose levels for VONJO are as follows: 200 mg twice daily (initial starting dose), 100 mg twice daily (first dose reduction), 100 mg once daily (second dose reduction). Discontinue VONJO in patients unable to tolerate a dose of 100 mg daily.
Toxicity | Management/Action |
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a Increase of at least 7 stools per day over baseline, or hospitalization indicated, or severe increase in ostomy output over baseline, or if limiting self care. |
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b Increase of <4 stools per day over baseline or mild increase in ostomy output compared to baseline. |
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New onset of diarrhea |
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Grade 3 or 4 a |
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Worsening Thrombocytopenia | Action |
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For clinically significant worsening of thrombocytopenia that lasts more than 7 days |
|
Toxicity | Action |
---|---|
Moderate bleeding; intervention indicated |
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Severe bleeding; transfusion, invasive intervention, or hospitalization indicated |
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Life-threatening bleeding; urgent intervention indicated. |
|
Toxicity | Action |
---|---|
QTc prolongation >500 msec or >60 msec from baseline |
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