Vistogard Dosage

Generic name: uridine triacetate 951mg in 1g
Dosage form: oral granules
Drug classes: Antidotes, Miscellaneous metabolic agents

Medically reviewed by Drugs.com. Last updated on Nov 6, 2023.

Recommended Dosage

Adults: 10 grams (1 packet) orally every 6 hours for 20 doses, without regard to meals.
Pediatric: 6.2 grams/m2 of body surface area (not to exceed 10 grams per dose) orally every 6 hours for 20 doses, without regard to meals. The VISTOGARD dose to be administered at 6.2 grams/m2 is presented in Table 1. Measure the dose using either a scale accurate to at least 0.1 gram, or a graduated teaspoon accurate to ¼ teaspoon. Discard any unused portion of granules. Do not use granules left in the open packet for subsequent dosing.

Table 1 VISTOGARD Pediatric Dose Based on Body Surface Area (m2)
Patient Body Surface Area (m2)	Table 1 VISTOGARD 6.2 grams/m2/dose*
Patient Body Surface Area (m2)	Dose in Grams	Dose in Graduated Teaspoons
* Dose by body surface area category in this table was rounded to achieve the approximate dose. Each dose is administered every 6 hours for 20 doses. † May use 1 entire 10 g packet without weighing or measuring. Do not exceed 10 grams/dose.
0.34 to 0.44	2.1 to 2.7	1
0.45 to 0.55	2.8 to 3.4	1 ¼
0.56 to 0.66	3.5 to 4.1	1 ½
0.67 to 0.77	4.2 to 4.8	1 ¾
0.78 to 0.88	4.9 to 5.4	2
0.89 to 0.99	5.5 to 6.1	2 ¼
1.00 to 1.10	6.2 to 6.8	2 ½
1.11 to 1.21	6.9 to 7.5	2 ¾
1.22 to 1.32	7.6 to 8.1	3
1.33 to 1.43	8.2 to 8.8	3 ¼
1.44 and above †	10.0	1 full packet †

Administer VISTOGARD as soon as possible after an overdose or early-onset toxicity within 96 hours following the end of fluorouracil or capecitabine administration.
Administer full course of VISTOGARD (20 doses) as directed.

Preparation and Administration

Mix each VISTOGARD dose with 3 to 4 ounces of soft foods such as applesauce, pudding or yogurt and ingest within 30 minutes. Do not chew the VISTOGARD granules. Drink at least 4 ounces of water.
If a patient vomits within 2 hours of taking a dose of VISTOGARD, initiate another complete dose as soon as possible after the vomiting episode. Administer the next dose at the regularly scheduled time.
If a patient misses a dose at the scheduled time, administer that dose of VISTOGARD as soon as possible. Administer the next dose at the regularly scheduled time.
Administer VISTOGARD via a nasogastric tube (NG tube) or gastrostomy tube (G-Tube) when necessary (eg, severe mucositis or coma). Follow the instructions below for each dose administration:
1. Prepare approximately 4 fluid ounces (about 100 mL) of a food starch-based thickening product in water and stir briskly until the thickener has dissolved.
2. Crush the contents of one full 10 gram packet of VISTOGARD granules to a fine powder.
3. Add the crushed VISTOGARD granules to 4 ounces (about 100 mL) of the reconstituted food starch-based thickening product. For pediatric patients receiving less than 10 grams, prepare the mixture at a ratio of no greater than 1 gram per 10 mL of reconstituted food starch-based thickening product and mix thoroughly.
4. After administration of the mixture using the NG tube or G-Tube, flush the tube with water.