Skip to main content

Vinorelbine Dosage

Medically reviewed by Drugs.com. Last updated on Apr 2, 2024.

Applies to the following strengths: 10 mg/mL

Usual Adult Dose for Non-Small Cell Lung Cancer

IN COMBINATION WITH CISPLATIN:
25 mg/m2 IV over 6 to 10 minutes on Days 1, 8, 15, and 21 of a 28-day cycle in combination with cisplatin 100 mg/m2 IV on Day 1 only of each 28-day cycle
OR
30 mg/m2 IV over 6 to 10 minutes once a week in combination with cisplatin 120 mg/m2 IV on Days 1 and 29, then every 6 weeks

AS A SINGLE AGENT:
30 mg/m2 IV over 6 to 10 minutes once a week

Uses:

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

DOSE MODIFICATIONS FOR HEPATIC TOXICITY:

Dose Adjustments

HEMATOLOGIC TOXICITY:
Hold or decrease the dose in patients with decreased neutrophil counts on the day of therapy using the following:


For patients who experience fever and/or sepsis while neutrophil count is less than 1500 cells/mm3 or had 2 consecutive weekly doses held due to neutropenia, subsequent doses of this drug should be:

HEPATIC TOXICITY:
Patients with elevated serum total bilirubin concentration:

CONCURRENT HEMATOLOGIC TOXICITY AND HEPATIC IMPAIRMENT: In patients with both hematologic toxicity and hepatic impairment, administer the lower of the doses based on the corresponding starting dose of this drug determined from the dose modifications for hematologic toxicity and dose modifications for hepatic toxicity.

NEUROLOGIC TOXICITY: Discontinue this drug for NCI CTCAE Grade 2 or higher peripheral neuropathy or autonomic neuropathy causing constipation.

Precautions

US BOXED WARNINGS:

Recommendation:

CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
IV FORMULATION:

CAPSULE FORMULATION:

Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:
This drug is compatible with all the following solutions:
5% Dextrose Injection
0.9% Sodium Chloride Injection
0.45% Sodium Chloride Injection
5% Dextrose and 0.45% Sodium Chloride Injection
Ringer's Injection
Lactated Ringer's Injection

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.