Vantin Dosage
Generic name: cefpodoxime proxetil 50mg in 5mL
Dosage form: granule, for suspension - tablet, film coated
Drug class: Third generation cephalosporins
Medically reviewed by Drugs.com. Last updated on Feb 12, 2024.
(See INDICATIONS AND USAGE for indicated pathogens.)
FILM-COATED TABLETS
VANTIN Tablets should be administered orally with food to enhance absorption. (See CLINICAL PHARMACOLOGY.)
The recommended dosages, durations of treatment, and applicable patient population are as described in the following chart:
Adults and Adolescents (age 12 years and older)
Type of Infection | Total Daily Dose |
Dose Frequency | Duration |
---|---|---|---|
Pharyngitis and/or tonsillitis | 200 mg | 100 mg Q 12 hours | 5 to 10 days |
Acute community-acquired pneumonia |
400 mg | 200 mg Q 12 hours | 14 days |
Acute bacterial exacerbations of chronic bronchitis |
400 mg | 200 mg Q 12 hours | 10 days |
Uncomplicated gonorrhea (men and women) and rectal gonococcal infections (women) |
200 mg | single dose | |
Skin and skin structure | 800 mg | 400 mg Q 12 hours | 7 to 14 days |
Acute maxillary sinusitis | 400 mg | 200 mg Q 12 hours | 10 days |
Uncomplicated urinary tract infection |
200 mg | 100 mg Q 12 hours | 7 days |
GRANULES FOR ORAL SUSPENSION
VANTIN Oral Suspension may be given without regard to food. The recommended dosages, durations of treatment, and applicable patient populations are as described in the following chart:
Adults and Adolescents (age 12 years and older)
Type of Infection | Total Daily Dose |
Dose Frequency | Duration |
---|---|---|---|
Pharyngitis and/or tonsillitis | 200 mg | 100 mg Q 12 hours | 5 to 10 days |
Acute community-acquired pneumonia |
400 mg | 200 mg Q 12 hours | 14 days |
Uncomplicated gonorrhea (men and women) and rectal gonococcal infections (women) |
200 mg | single dose | |
Skin and skin structure | 800 mg | 400 mg Q 12 hours | 7 to 14 days |
Acute maxillary sinusitis | 400 mg | 200 mg Q 12 hours | 10 days |
Uncomplicated urinary tract infection |
200 mg | 100 mg Q 12 hours | 7 days |
Infants and Pediatric Patients (age 2 months through 12 years)
Type of Infection | Total Daily Dose |
Dose Frequency | Duration |
---|---|---|---|
Acute otitis media | 10 mg/kg/day (Max 400 mg/day) |
5 mg/kg Q 12 h (Max 200 mg/dose) |
5 days |
Pharyngitis and/or tonsillitis | 10 mg/kg/day (Max 200 mg/day) |
5 mg/kg/dose Q 12 h (Max 100 mg/dose) |
5 to 10 days |
Acute maxillary sinusitis | 10 mg/kg/day (Max 400 mg/day) |
5 mg/kg Q 12 hours (Max 200 mg/dose) |
10 days |
Patients with Renal Dysfunction
For patients with severe renal impairment (<30 mL/min creatinine clearance), the dosing intervals should be increased to Q 24 hours. In patients maintained on hemodialysis, the dose frequency should be 3 times/week after hemodialysis.
When only the serum creatinine level is available, the following formula (based on sex, weight, and age of the patient) may be used to estimate creatinine clearance (mL/min). For this estimate to be valid, the serum creatinine level should represent a steady state of renal function.
Males: (mL/min) |
Weight (kg) × (140 - age) 72 × serum creatinine (mg/100 mL) |
Females: (mL/min) |
0.85 × above value |
Patients with Cirrhosis
Cefpodoxime pharmacokinetics in cirrhotic patients (with or without ascites) are similar to those in healthy subjects. Dose adjustment is not necessary in this population.
Preparation of Suspension
Constituted Volume |
Final Concentration |
Directions |
---|---|---|
50 mL | 50 mg per 5 mL | Suspend in a total of 29 mL of distilled water. Method: First, shake the bottle to loosen granules. Then add the water in two approximately equal portions, shaking vigorously after each aliquot of water. |
75 mL | 50 mg per 5 mL | Suspend in a total of 44 mL of distilled water. Method: First, shake the bottle to loosen granules. Then add the water in two approximately equal portions, shaking vigorously after each aliquot of water. |
100 mL | 50 mg per 5 mL | Suspend in a total of 58 mL of distilled water. Method: First, shake the bottle to loosen granules. Then add the water in two approximately equal portions, shaking vigorously after each aliquot of water. |
50 mL | 100 mg per 5 mL | Suspend in a total of 29 mL of distilled water. Method: First, shake the bottle to loosen granules. Then add the water in two approximately equal portions, shaking vigorously after each aliquot of water. |
75 mL | 100 mg per 5 mL | Suspend in a total of 43 mL of distilled water. Method: First, shake the bottle to loosen granules. Then add the water in two approximately equal portions, shaking vigorously after each aliquot of water. |
100 mL | 100 mg per 5 mL | Suspend in a total of 57 mL of distilled water. Method: First, shake the bottle to loosen granules. Then add the water in two approximately equal portions, shaking vigorously after each aliquot of water. |
After mixing, the suspension should be stored in a refrigerator, 2° to 8°C (36° to 46°F). Shake well before using. Keep container tightly closed. The mixture may be used for 14 days. Discard unused portion after 14 days.
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