Skip to main content

Vandetanib Dosage

Medically reviewed by Drugs.com. Last updated on Apr 23, 2024.

Applies to the following strengths: 100 mg; 300 mg

Usual Adult Dose for Thyroid Cancer

Initial dose: 300 mg orally once daily.
Duration of therapy: Continue drug until disease progression or unacceptable toxicity occurs.

Use: For the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.

Renal Dose Adjustments

Mild renal impairment (CrCl 50 mL/min or greater): No dose adjustment recommended.
Moderate to severe renal impairment (CrCl less than 50 mL/min): Initial dose: 200 mg orally once daily.

Liver Dose Adjustments

Mild hepatic impairment: No dose adjustment recommended.
Moderate and severe hepatic impairment: Use not recommended.

Dose Adjustments

QT Interval Prolongation:


For Adverse Reactions:

For Recurrent Toxicities:

Due to long half-life (19 hours), adverse reactions, including QT prolongation, may take weeks to resolve; continued monitoring will be necessary.

Precautions

US REMS: The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for this drug. It includes a medication guide, communication plan, elements to assure safe use, and implementation system. For additional information: www.fda.gov/REMS.

US BOXED WARNINGS:

Recommendations:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


General:

Monitoring:

Patient Advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.