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Thioguanine Dosage

Medically reviewed by Drugs.com. Last updated on Apr 15, 2024.

Applies to the following strengths: 40 mg

Usual Adult Dose for Acute Myeloid Leukemia

Combination therapy:
The dose which will be tolerated and effective varies according to the stage and type of cancer being treated. Because the usual therapies involve the use of this drug with other agents in combination, physicians administering these therapies should be experienced in the use of cancer chemotherapy and in the institutional protocol.

Single agent therapy:
2 mg/kg orally daily; if, after 4 weeks there is no improvement and no leukocyte or platelet depression, the dose may be increased to 3 mg/kg orally daily; the total daily dose may be given at one time

Comments:


Use: For remission induction and remission consolidation treatment of acute myeloid leukemia; however, it is not recommended for use during maintenance therapy or similar long-term continuous treatments due to the high risk of liver toxicity

Usual Adult Dose for Acute Nonlymphocytic Leukemia

Combination therapy:
The dose which will be tolerated and effective varies according to the stage and type of cancer being treated. Because the usual therapies involve the use of this drug with other agents in combination, physicians administering these therapies should be experienced in the use of cancer chemotherapy and in the institutional protocol.

Single agent therapy:
2 mg/kg orally daily; if, after 4 weeks there is no improvement and no leukocyte or platelet depression, the dose may be increased to 3 mg/kg orally daily; the total daily dose may be given at one time

Comments:


Use: For remission induction and remission consolidation treatment of acute myeloid leukemia; however, it is not recommended for use during maintenance therapy or similar long-term continuous treatments due to the high risk of liver toxicity

Usual Pediatric Dose for Acute Myeloid Leukemia

Combination therapy:
The dose which will be tolerated and effective varies according to the stage and type of cancer being treated. Because the usual therapies involve the use of this drug with other agents in combination, physicians administering these therapies should be experienced in the use of cancer chemotherapy and in the institutional protocol.

Single agent therapy:
2 mg/kg orally daily; if, after 4 weeks there is no improvement and no leukocyte or platelet depression, the dose may be increased to 3 mg/kg orally daily; the total daily dose may be given at one time

Comments:


Use: For remission induction and remission consolidation treatment of acute myeloid leukemia; however, it is not recommended for use during maintenance therapy or similar long-term continuous treatments due to the high risk of liver toxicity

Usual Pediatric Dose for Acute Nonlymphocytic Leukemia

Combination therapy:
The dose which will be tolerated and effective varies according to the stage and type of cancer being treated. Because the usual therapies involve the use of this drug with other agents in combination, physicians administering these therapies should be experienced in the use of cancer chemotherapy and in the institutional protocol.

Single agent therapy:
2 mg/kg orally daily; if, after 4 weeks there is no improvement and no leukocyte or platelet depression, the dose may be increased to 3 mg/kg orally daily; the total daily dose may be given at one time

Comments:


Use: For remission induction and remission consolidation treatment of acute myeloid leukemia; however, it is not recommended for use during maintenance therapy or similar long-term continuous treatments due to the high risk of liver toxicity

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Caution recommended.

Dose Adjustments

Patients with homozygous deficiency of either TPMT or NUDT15 enzyme usually require 10% or less of the standard dose. Reduce initial dosage in patients who are known to have homozygous TPMT or NUDT15 deficiency. Most patients with heterozygous TPMT or NUDT15 deficiency tolerate recommended thioguanine doses, but some require dose reduction based on toxicities. Patients who are heterozygous for both TPMT and NUDT15 may require more substantial dosage reductions. Reduce the dosage based on tolerability.

Precautions

CONTRAINDICATIONS:


Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.