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Tepotinib Dosage

Medically reviewed by Drugs.com. Last updated on Aug 5, 2024.

Applies to the following strengths: 225 mg

Usual Adult Dose for Non-Small Cell Lung Cancer

450 mg orally once a day
Duration of therapy: Until disease progression or unacceptable toxicity

Use: For the treatment of patients with metastatic non-small cell lung cancer (NSCLC) harboring mesenchymal-epithelial transition (MET) exon 14 skipping alterations

Renal Dose Adjustments

Mild or moderate renal dysfunction (CrCl 30 to 89 mL/min): No adjustment recommended.
Severe renal dysfunction (CrCl less than 30 mL/min): Data not available

Comments:

Liver Dose Adjustments

Mild or moderate liver dysfunction (Child-Pugh A or B): No adjustment recommended.
Severe liver dysfunction (Child-Pugh C): Data not available

During Therapy:
Increased ALT and/or AST without increased total bilirubin:


Increased ALT and/or AST with increased total bilirubin (without cholestasis or hemolysis):

Increased total bilirubin without concurrent increased ALT and/or AST:

Comments:

Dose Adjustments

Recommended dose reduction for adverse reaction management: 225 mg orally once a day
If patients are unable to tolerate 225 mg/day: This drug should be permanently discontinued.

Interstitial Lung Disease (ILD)/Pneumonitis:


Other Adverse Reactions:

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.