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Tapentadol Dosage

Medically reviewed by Drugs.com. Last updated on Jan 16, 2024.

Applies to the following strengths: 50 mg; 75 mg; 100 mg; 150 mg; 200 mg; 250 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Pain

IMMEDIATE-RELEASE (IR) TABLETS OR ORAL SOLUTION:
Initial Dose: 50 to 100 mg orally every 4 to 6 hours, as needed for pain

Maintenance Dose: 50, 75, or 100 mg orally every 4 to 6 hours, adjusted to maintain adequate analgesia with acceptable tolerability
Maximum Dose: 700 mg/day on the first day of therapy; 600 mg/day on subsequent days

CONVERSION FROM TAPENTADOL IR TABLETS/ORAL SOLUTION TO EXTENDED-RELEASE (ER) TABLETS:

Comments:

Use: For the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate

Usual Adult Dose for Neuropathic Pain

EXTENDED-RELEASE TABLETS:
Initial Dose (in opioid-naive/not opioid tolerant patients): 50 mg orally twice a day, about every 12 hours
Maintenance Dose: Titrate to adequate analgesia by 50 mg no more than twice a day every 3 days to a recommended dosage range of 100 to 250 mg orally twice a day.
Maximum Dose: 500 mg/day

CONVERSION FROM TAPENTADOL IR TABLETS/ORAL SOLUTION TO ER TABLETS:


CONVERSION FROM OTHER OPIOIDS (INCLUDING METHADONE) TO TAPENTADOL ER:

Comments:

Uses:

Usual Adult Dose for Chronic Pain

EXTENDED-RELEASE TABLETS:
Initial Dose (in opioid-naive/not opioid tolerant patients): 50 mg orally twice a day, about every 12 hours
Maintenance Dose: Titrate to adequate analgesia by 50 mg no more than twice a day every 3 days to a recommended dosage range of 100 to 250 mg orally twice a day.
Maximum Dose: 500 mg/day

CONVERSION FROM TAPENTADOL IR TABLETS/ORAL SOLUTION TO ER TABLETS:


CONVERSION FROM OTHER OPIOIDS (INCLUDING METHADONE) TO TAPENTADOL ER:

Comments:

Uses:

Usual Pediatric Dose for Pain

6 years or older:
IMMEDIATE-RELEASE TABLETS:
Weight 40 to 59 kg:


Weight 60 to 79 kg:

Weight 80 kg or greater:

ORAL SOLUTION:
Weight 16 kg to less than 40 kg:

Weight 40 kg or greater:

Comments:

Use: For the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate

Renal Dose Adjustments

ADULTS:
Mild to moderate renal dysfunction (CrCl 30 to 90 mL/min): No adjustment recommended
Severe renal dysfunction (CrCl less than 30 mL/min): Not recommended

PEDIATRIC:
Renal dysfunction: Use is not recommended in this population; data not available.

Liver Dose Adjustments

ADULTS:
Mild Liver Dysfunction (Child-Pugh Score 5 to 6): No adjustment recommended

Moderate Liver Dysfunction (Child-Pugh Score 7 to 9):
IR Tablets/Oral Solution:

ER Tablets:

Severe Liver Dysfunction (Child-Pugh Score 10 to 15): Not recommended; data not available

PEDIATRIC:
Liver Dysfunction: Use is not recommended in this population; data not available.

Dose Adjustments

RECOMMENDATIONS FOR DOSE REDUCTION OR THERAPY DISCONTINUATION:

Precautions

The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for all opioids intended for outpatient use. The new FDA Opioid Analgesic REMS is a designed to assist in communicating the serious risks of opioid pain medications to patients and health care professionals. It includes a medication guide and elements to assure safe use. For information on opioid analgesic REMS visit www.opioidanalgesicrems.com or call 1-800-503-0784. For additional information visit www.accessdata.fda.gov/scripts/cder/rems/index.cfm

US BOXED WARNINGS:


CONTRAINDICATIONS:

IR Tablets: Safety and efficacy have not been established in patients younger than 6 years old weighing less than 40 kg
ER Tablets: Safety and efficacy have not been established in patients younger than 18 years
Oral Solution: Safety and efficacy have not been established in patients younger than 6 years old weighing less than 16 kg

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule II

Dialysis

Data not available

Other Comments

Administration advice:
All Formulations:


Oral Solution:

ER Tablets:

Storage requirements:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.