Taliglucerase Alfa Dosage

Medically reviewed by Drugs.com. Last updated on Nov 1, 2023.

Applies to the following strengths: 200 units

Usual Adult Dose for Gaucher Disease

Treatment-naive:

Conversion from imiglucerase:

For patients on a stable dose of imiglucerase: Begin at same units/kg dose IV every other week

Dose adjustments should be based on individual's therapeutic goals

Comments:

Administer as an IV infusion over 60 to 120 minutes every other week; in adult patients, an initial infusion rate of 1.2 mL/minute should be used.
After tolerability to infusion is established, the infusion rate may be increased, but should not exceed the maximum recommended infusion rate of 2.2 mL/minute; infusion should be delivered over a minimum or 60 minutes.

Use: For long-term enzyme replacement therapy (ERT) for patients with confirmed diagnosis of type 1 Gaucher disease

4 years or older:
Treatment-naive: Initial dose: 60 units/kg IV every other week

Conversion from imiglucerase:

For patients on a stable dose of imiglucerase: Begin with same units/kg dose IV every other week

Dose adjustments should be based on individual's therapeutic goals

Comments:

Administer as an IV infusion over 60 to 120 minutes every other week; in adult patients, an initial infusion rate of 1.2 mL/minute should be used.
After tolerability to infusion is established, the infusion rate may be increased, but should not exceed the maximum recommended infusion rate of 2.2 mL/minute; infusion should be delivered over a minimum or 60 minutes.

Use: For the treatment of patients with a confirmed diagnosis of Type 1 Gaucher disease.

No adjustment recommended

No adjustment recommended

CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 4 years.

Consult WARNINGS section for additional precautions.

Data not available

Administration Advice:

For IV infusion over a minimum of 60 minutes every other week
Due to the potential for anaphylaxis, appropriate medical support should be readily available during administration

Adults:

Pediatrics:

Maximum infusion rate: 2 mL/min

Reconstitution/preparation techniques:

Should be prepared under the supervision of a healthcare professional; consult product labeling for additional instructions
Reconstitute each vial with 5.1 mL of Sterile Water for Injection to yield a concentration of 40 units/mL and an extractable volume of 5 mL; upon reconstitution, mix vials gently, do not shake
Further dilute with 0.9% sodium chloride to a final volume of 100 or 200 mL
Following reconstitution and dilution, administer via IV infusion; filter through an in-line low-protein-binding 0.2 micrometer filter

Storage Requirements:

Store in refrigerator at 2C to 8C (36F to 46F); protect from light
Reconstituted product: May store for up to 24 hours when refrigerated (2C to 8C [36F to 46F]) and protected from light OR up to 4 hours at 20C to 25C (68F to 77F) without protection from light
Diluted product: May store for up to 24 hours at 2C to 8C (36F to 46F) when protected from light
Storage of reconstituted product and diluted products should not exceed a total of 24 hours
Do not freeze

Monitoring:

Hypersensitivity: Signs/symptoms of allergic reactions and/or infusion-related reactions (during and after infusion)

Patient Advice:

Patients and caregivers should understand that infusion-related and hypersensitivity reactions including anaphylaxis may occur with therapy.
Patients and caregivers should be informed of the signs and symptoms of anaphylaxis and hypersensitivity reactions and should be instructed to seek medical care should signs and symptoms occur.