OraVerse Dosage

Generic name: Phentolamine Mesylate 0.235mg in 1mL
Dosage form: injection, solution
Drug class: Miscellaneous cardiovascular agents

Medically reviewed by Drugs.com. Last updated on Nov 27, 2023.

General Dosing information

The recommended dose of OraVerse is based on the number of cartridges of local anesthetic with vasoconstrictor administered:

Amount of Local Anesthetic Administered	Dose of OraVerse [mg]	Dose of OraVerse [Cartridge(s)]
1/4 Cartridge	0.1	1/4
½ Cartridge	0.2	½
1 Cartridge	0.4	1
2 Cartridges	0.8	2

OraVerse should be administered following the dental procedure using the same location(s) and technique(s) (infiltration or block injection) employed for the administration of the local anesthetic.

Chemically disinfect the carpule cap by wiping with either isopropyl alcohol (91%) or ethyl alcohol (70%). Many commercially available brands of isopropyl (rubbing) alcohol, as well as solutions of ethyl alcohol not of U.S.P. grade, contain denaturants that are injurious to rubber and therefore are not to be used. Inspect carpules visually prior to administration and do not use if particulate matter, discoloration, cracks in the glass, protruding plungers or other defects are observed.

Note: Do not administer OraVerse if particulate matter, discoloration, cracks in the glass, protruding plungers or other defects are observed.

Dosing in Special Populations

In pediatric patients weighing between ≥15 kg and <30 kg, the maximum dose of OraVerse recommend is ½ cartridge (0.2 mg).
(Note: Use in pediatric patients under 3years of age or weighing less than15 kg (33 lbs) is not recommended. A dose of more than 1 cartridge [0.4 mg] of OraVerse has not been studied in children less than 4 years of age.)