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Metreleptin Dosage

Medically reviewed by Drugs.com. Last updated on Jul 26, 2024.

Applies to the following strengths: 11.3 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Lipodystrophy

Weight 40 kg or less (males and females):


Weight greater than 40 kg:

Comments: Dose adjustments should be made based on clinical response (e.g., metabolic control) or other considerations (e.g., tolerability issues, excessive weight loss).

Use: As an adjunct to diet, used as replacement therapy to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy.

Usual Pediatric Dose for Lipodystrophy

Weight 40 kg or less (males and females):


Weight greater than 40 kg:

Comments: Dose adjustments should be made based on clinical response (e.g., metabolic control) or other considerations (e.g., tolerability issues, excessive weight loss).

Use: As an adjunct to diet, used as replacement therapy to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy.

Renal Dose Adjustments

Dose adjustment may be required; however, no specific guidelines have been suggested. Caution is recommended

Liver Dose Adjustments

No adjustment recommended

Dose Adjustments

Dose adjustments of medications known to cause hypoglycemia:


Discontinuation in patients at risk for pancreatitis:

Precautions

The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for Metreleptin. It includes elements to assure safe use, and implementation system. For additional information: http://www.accessdata.fda.gov/scripts/cder/rems/index.cfm.

US BOXED WARNINGS: RISK OF ANTI-METRELEPTIN ANTIBODIES WITH NEUTRALIZING ACTIVITY AND RISK OF LYMPHOMA:


Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Reconstitution/preparation techniques:

Storage:

Compatibility:

General: Limitations of use:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.