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Metoclopramide Dosage

Medically reviewed by Drugs.com. Last updated on Aug 9, 2023.

Applies to the following strengths: 10 mg; 5 mg; 5 mg/5 mL; 5 mg/mL; 10 mg/mL; 15 mg/actuation

Usual Adult Dose for Nausea/Vomiting - Chemotherapy Induced

EMETOGENIC CANCER CHEMOTHERAPY:
Parenteral:


Comments:

POSTOPERATIVE NAUSEA AND VOMITING:
Parenteral: 10 to 20 mg IM at or near the end of surgery

Uses:

Usual Adult Dose for Nausea/Vomiting - Postoperative

EMETOGENIC CANCER CHEMOTHERAPY:
Parenteral:


Comments:

POSTOPERATIVE NAUSEA AND VOMITING:
Parenteral: 10 to 20 mg IM at or near the end of surgery

Uses:

Usual Adult Dose for Small Intestine Intubation

If the tube has not passed the pylorus with conventional maneuvers in 10 minutes, a single undiluted dose may be administered via slow IV.

Parenteral: 10 mg IV metoclopramide base over a 1- to 2-minute period

Use: To facilitate small bowel intubation in patients in whom the tube does not pass the pylorus with conventional measures

Usual Adult Dose for Radiographic Exam

In patients where delayed gastric emptying interferes with radiological examination of the stomach and/or small intestine, a single IV dose may be administered.

Parenteral: 10 mg IV metoclopramide base over a 1 to 2-minute period

Use: Stimulate gastric emptying and intestinal transit of barium in cases where delayed emptying interferes with radiological examination of the stomach and/or small intestine

Usual Adult Dose for Gastroparesis

Parenteral: 10 mg IV (slowly over a 1 to 2-minute period) or IM


Oral: 10 mg orally 30 minutes before each meal and at bedtime for 2 to 8 weeks, depending upon response and the likelihood of continued well-being upon drug discontinuation

Comments:

Use: For the relief of symptoms associated with acute and recurrent diabetic gastric stasis/gastroparesis

Usual Adult Dose for Gastroesophageal Reflux Disease

Oral:


Comments:

Use: For the relief of symptomatic GERD in patients who fail to respond to conventional therapy

Usual Pediatric Dose for Small Intestine Intubation

If the tube has not passed the pylorus with conventional maneuvers in 10 minutes, a single undiluted dose may be administered via slow IV.
Parenteral:
6 years or younger: 0.1 mg/kg metoclopramide base IV over a 1 to 2 minute period
6 to 14 years: 2.5 to 5 mg metoclopramide base IV over a 1 to 2 minute period
14 years or older: 10 mg metoclopramide base IV over a 1 to 2 minute period

Comment: A single dose IV may be used if delayed gastric emptying interferes with radiological examination of the stomach and/or small intestine.

Uses:

Renal Dose Adjustments

Parenteral and oral dissolving tablets:
CrCl 40 mL/min or greater: No adjustment recommended
CrCl less than 40 mL/min: Initial doses should be 50% of the usual recommended dose; subsequent dose adjustments should be made according to patient response and tolerability.

Oral tablets:
DIABETIC GASTROPARESIS:
Mild renal dysfunction (CrCl 60 mL/min or greater): No adjustment recommended
Moderate to severe renal dysfunction (CrCl less than 60 mL/min): 5 mg orally 4 times a day (30 minutes before each meal and at bedtime)

End-stage renal disease (ESRD): 5 mg orally 4 times a day (30 minutes before each meal and at bedtime) OR 10 mg orally 2 times a day

GERD:
Mild renal dysfunction (CrCl 60 mL/min or greater): No adjustment recommended
Moderate to severe renal dysfunction (CrCl less than 60 mL/min): 5 mg orally 4 times a day (30 minutes before each meal and at bedtime)
ESRD: 5 mg orally 2 times a day

Liver Dose Adjustments

Parenteral and oral dissolving tablets: No adjustment recommended.

Oral tablets:
DIABETIC GASTROPARESIS:
Mild liver dysfunction (Child-Pugh A): 10 mg orally 4 times a day (30 minutes before each meal and at bedtime)

Moderate to severe liver dysfunction (Child-Pugh B and C): 5 mg orally 4 times a day (30 minutes before each meal and at bedtime)

GERD:
Mild liver dysfunction (Child-Pugh A): 10 to 15 mg orally 4 times a day (30 minutes before each meal and at bedtime)
Moderate to severe liver dysfunction (Child-Pugh B and C): 5 mg orally 4 times a day OR 10 mg orally 3 times a day

Dose Adjustments

Parenteral and oral dissolving tablets:


Oral tablets:
CYP450 2D6 poor metabolizers OR use with strong CYP450 2D6 inhibitors:
DIABETIC GASTROPARESIS: 5 mg orally 4 times a day (30 minutes before each meal and at bedtime)

GERD: 5 mg orally 4 times a day (30 minutes before each meal and at bedtime) OR 10 mg orally 3 times a day

Precautions

US BOXED WARNINGS:
TARDIVE DYSKINESIA:


Safety and effectiveness of oral formulations (e.g., tablets, disintegrating tablets, solution) have not been established in pediatric patients (less than 18 years of age).
Safety and effectiveness of injection formulations have not been established in pediatric patients (less than 18 years of age) except to facilitate small bowel intubation.

Consult WARNINGS section for additional precautions.

Dialysis

US/CA:
Parenteral and oral dissolving tablets: Data not available

Oral tablets:
DIABETIC GASTROPARESIS:
Hemodialysis or continuous ambulatory peritoneal dialysis: 5 mg orally 4 times a day (30 minutes before each meal and at bedtime) OR 10 mg orally 2 times a day


GERD:
Hemodialysis or continuous ambulatory peritoneal dialysis: 5 mg orally 2 times a day

Other Comments

Administration advice:


Reconstitution/preparation techniques:

Storage requirements:

General:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.