Skip to main content

Methylene Blue Dosage

Medically reviewed by Drugs.com. Last updated on Jul 2, 2024.

Applies to the following strengths: 65 mg; 10 mg/mL; 5 mg/mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Methemoglobinemia

Drug-Induced Methemoglobinemia:
Methylene blue injection 1%:
0.1 to 0.2 mL/kg IV very slowly over a period of several minutes; may repeat in one hour if necessary

Acquired Methemoglobinemia:
Methylene blue injection 0.5% [Provayblue (TM)]:
1 mg/kg IV over 5 to 30 minutes; if the methemoglobin level remains greater than 30% or if symptoms persist, a repeat dose of 1 mg/kg IV may be given one hour after the first dose; if methemoglobinemia does not resolve after 2 doses, consider alternative interventions

Comments:


Uses:
Methylene blue injection 1%: Drug-induced methemoglobinemia
Methylene blue injection 0.5% [Provayblue (TM)]: Acquired methemoglobinemia

Usual Pediatric Dose for Methemoglobinemia

Drug-Induced Methemoglobinemia:
Methylene blue injection 1%:
0.1 to 0.2 mL/kg IV very slowly over a period of several minutes; may repeat in one hour if necessary

Acquired Methemoglobinemia:
Methylene blue injection 0.5% [Provayblue (TM)]:
1 mg/kg IV over 5 to 30 minutes; if the methemoglobin level remains greater than 30% or if symptoms persist, a repeat dose of 1 mg/kg IV may be given one hour after the first dose; if methemoglobinemia does not resolve after 2 doses, consider alternative interventions

Comments:


Uses:
Methylene blue injection 1%: Drug-induced methemoglobinemia
Methylene blue injection 0.5% [Provayblue (TM)]: Acquired methemoglobinemia

Renal Dose Adjustments

Approximately 40% of this drug is excreted by the kidneys. Patients with any renal impairment should be monitored for toxicities and potential drug interactions for an extended period following therapy.

Liver Dose Adjustments

Methylene blue is extensively metabolized in the liver. Monitor patients with any hepatic impairment for toxicities and potential drug interactions for an extended period following therapy.

Precautions

US BOXED WARNINGS:
WARNING: SEROTONIN SYNDROME WITH CONCOMITANT USE OF SEROTONERGIC DRUGS:


Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.