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Methotrimeprazine Dosage

Applies to the following strengths: 20 mg/mL

Usual Adult Dose for Anxiety

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):


PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day

Comments:

Uses:

Usual Adult Dose for Depression

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):


PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day

Comments:

Uses:

Usual Adult Dose for Mania

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):


PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day

Comments:

Uses:

Usual Adult Dose for Pain

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):


PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day

Comments:

Uses:

Usual Adult Dose for Psychosis

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):


PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day

Comments:

Uses:

Usual Adult Dose for Trigeminal Neuralgia

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):


PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day

Comments:

Uses:

Usual Adult Dose for Schizophrenia

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):


PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day

Comments:

Uses:

Usual Adult Dose for Nausea/Vomiting

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):


PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day

Comments:

Uses:

Usual Adult Dose for Neuropathic Pain

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):


PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day

Comments:

Uses:

Usual Adult Dose for Breakthrough Pain

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):


PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day

Comments:

Uses:

Usual Adult Dose for Insomnia

ORAL:


PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day

Comments:

Uses:

Usual Adult Dose for Sedation

ORAL:


PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day

Comments:

Uses:

Usual Pediatric Dose for Anxiety

ORAL:
Children:


PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:

Uses:

Usual Pediatric Dose for Depression

ORAL:
Children:


PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:

Uses:

Usual Pediatric Dose for Insomnia

ORAL:
Children:


PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:

Uses:

Usual Pediatric Dose for Mania

ORAL:
Children:


PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:

Uses:

Usual Pediatric Dose for Pain

ORAL:
Children:


PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:

Uses:

Usual Pediatric Dose for Psychosis

ORAL:
Children:


PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:

Uses:

Usual Pediatric Dose for Sedation

ORAL:
Children:


PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:

Uses:

Usual Pediatric Dose for Trigeminal Neuralgia

ORAL:
Children:


PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:

Uses:

Usual Pediatric Dose for Schizophrenia

ORAL:
Children:


PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:

Uses:

Usual Pediatric Dose for Nausea/Vomiting

ORAL:
Children:


PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:

Uses:

Usual Pediatric Dose for Neuropathic Pain

ORAL:
Children:


PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:

Uses:

Usual Pediatric Dose for Breakthrough Pain

ORAL:
Children:


PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:

Uses:

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Contraindicated

Dose Adjustments

Patients with arteriosclerosis or cardiovascular disorders: Patients should begin with low initial treatment doses.

Large initial oral doses: Patients should be kept in bed for the first few days.

Patients taking other phenothiazines and/or central nervous system (CNS) depressants concomitantly: The usual dose of these agent(s) should be decreased by 50% if they are taken concomitantly until the dose of this drug is established.

Parenteral doses for adjunctive post-operative analgesia of 10 to 25 mg every 8 hours are equivalent to 20 to 40 mg oral doses.

Precautions

CONTRAINDICATIONS:


Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.