Methotrimeprazine Dosage
Applies to the following strengths: 20 mg/mL
Usual Adult Dose for:
- Anxiety
- Depression
- Mania
- Pain
- Psychosis
- Trigeminal Neuralgia
- Schizophrenia
- Nausea/Vomiting
- Neuropathic Pain
- Breakthrough Pain
- Insomnia
- Sedation
Usual Pediatric Dose for:
- Anxiety
- Depression
- Insomnia
- Mania
- Pain
- Psychosis
- Sedation
- Trigeminal Neuralgia
- Schizophrenia
- Nausea/Vomiting
- Neuropathic Pain
- Breakthrough Pain
Additional dosage information:
Usual Adult Dose for Anxiety
ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
- Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
- Maximum dose: 1000 mg/day
PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
- Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.
Uses:
- As an adjunct to post-operative analgesia
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomfort
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Treatment of acute schizophrenia
- Treatment of chronic schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Adult Dose for Depression
ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
- Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
- Maximum dose: 1000 mg/day
PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
- Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.
Uses:
- As an adjunct to post-operative analgesia
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomfort
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Treatment of acute schizophrenia
- Treatment of chronic schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Adult Dose for Mania
ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
- Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
- Maximum dose: 1000 mg/day
PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
- Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.
Uses:
- As an adjunct to post-operative analgesia
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomfort
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Treatment of acute schizophrenia
- Treatment of chronic schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Adult Dose for Pain
ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
- Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
- Maximum dose: 1000 mg/day
PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
- Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.
Uses:
- As an adjunct to post-operative analgesia
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomfort
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Treatment of acute schizophrenia
- Treatment of chronic schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Adult Dose for Psychosis
ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
- Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
- Maximum dose: 1000 mg/day
PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
- Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.
Uses:
- As an adjunct to post-operative analgesia
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomfort
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Treatment of acute schizophrenia
- Treatment of chronic schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Adult Dose for Trigeminal Neuralgia
ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
- Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
- Maximum dose: 1000 mg/day
PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
- Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.
Uses:
- As an adjunct to post-operative analgesia
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomfort
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Treatment of acute schizophrenia
- Treatment of chronic schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Adult Dose for Schizophrenia
ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
- Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
- Maximum dose: 1000 mg/day
PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
- Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.
Uses:
- As an adjunct to post-operative analgesia
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomfort
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Treatment of acute schizophrenia
- Treatment of chronic schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Adult Dose for Nausea/Vomiting
ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
- Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
- Maximum dose: 1000 mg/day
PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
- Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.
Uses:
- As an adjunct to post-operative analgesia
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomfort
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Treatment of acute schizophrenia
- Treatment of chronic schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Adult Dose for Neuropathic Pain
ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
- Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
- Maximum dose: 1000 mg/day
PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
- Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.
Uses:
- As an adjunct to post-operative analgesia
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomfort
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Treatment of acute schizophrenia
- Treatment of chronic schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Adult Dose for Breakthrough Pain
ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
- Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
- Maximum dose: 1000 mg/day
PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
- Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.
Uses:
- As an adjunct to post-operative analgesia
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomfort
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Treatment of acute schizophrenia
- Treatment of chronic schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Adult Dose for Insomnia
ORAL:
- Initial dose: 6 to 25 mg orally per day, given in 3 divided doses with meals
- Sedative: 10 to 25 mg orally once a day at night
PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
Comments:
- Doses should be determined by the condition and the patient's response.
- Initial doses should be increased until an optimal level is achieved.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
Uses:
- As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
- Management of insomnia
Usual Adult Dose for Sedation
ORAL:
- Initial dose: 6 to 25 mg orally per day, given in 3 divided doses with meals
- Sedative: 10 to 25 mg orally once a day at night
PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
Comments:
- Doses should be determined by the condition and the patient's response.
- Initial doses should be increased until an optimal level is achieved.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
Uses:
- As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
- Management of insomnia
Usual Pediatric Dose for Anxiety
ORAL:
Children:
- Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
- Maximum dose: 40 mg/day (in children less than 12 years)
PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses
IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- IV formulations should be administered in the context of palliative care.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Oral formulations should be substituted for parenteral formulations as soon as possible.
- Initial doses should be increased until an optimal level is achieved.
Uses:
- As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
- As an adjunct to post-operative analgesia
- As an analgesic in muscular discomforts
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomforts
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Management of insomnia
- Treatment of acute schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of chronic schizophrenia
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Pediatric Dose for Depression
ORAL:
Children:
- Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
- Maximum dose: 40 mg/day (in children less than 12 years)
PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses
IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- IV formulations should be administered in the context of palliative care.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Oral formulations should be substituted for parenteral formulations as soon as possible.
- Initial doses should be increased until an optimal level is achieved.
Uses:
- As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
- As an adjunct to post-operative analgesia
- As an analgesic in muscular discomforts
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomforts
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Management of insomnia
- Treatment of acute schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of chronic schizophrenia
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Pediatric Dose for Insomnia
ORAL:
Children:
- Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
- Maximum dose: 40 mg/day (in children less than 12 years)
PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses
IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- IV formulations should be administered in the context of palliative care.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Oral formulations should be substituted for parenteral formulations as soon as possible.
- Initial doses should be increased until an optimal level is achieved.
Uses:
- As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
- As an adjunct to post-operative analgesia
- As an analgesic in muscular discomforts
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomforts
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Management of insomnia
- Treatment of acute schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of chronic schizophrenia
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Pediatric Dose for Mania
ORAL:
Children:
- Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
- Maximum dose: 40 mg/day (in children less than 12 years)
PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses
IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- IV formulations should be administered in the context of palliative care.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Oral formulations should be substituted for parenteral formulations as soon as possible.
- Initial doses should be increased until an optimal level is achieved.
Uses:
- As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
- As an adjunct to post-operative analgesia
- As an analgesic in muscular discomforts
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomforts
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Management of insomnia
- Treatment of acute schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of chronic schizophrenia
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Pediatric Dose for Pain
ORAL:
Children:
- Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
- Maximum dose: 40 mg/day (in children less than 12 years)
PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses
IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- IV formulations should be administered in the context of palliative care.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Oral formulations should be substituted for parenteral formulations as soon as possible.
- Initial doses should be increased until an optimal level is achieved.
Uses:
- As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
- As an adjunct to post-operative analgesia
- As an analgesic in muscular discomforts
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomforts
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Management of insomnia
- Treatment of acute schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of chronic schizophrenia
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Pediatric Dose for Psychosis
ORAL:
Children:
- Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
- Maximum dose: 40 mg/day (in children less than 12 years)
PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses
IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- IV formulations should be administered in the context of palliative care.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Oral formulations should be substituted for parenteral formulations as soon as possible.
- Initial doses should be increased until an optimal level is achieved.
Uses:
- As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
- As an adjunct to post-operative analgesia
- As an analgesic in muscular discomforts
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomforts
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Management of insomnia
- Treatment of acute schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of chronic schizophrenia
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Pediatric Dose for Sedation
ORAL:
Children:
- Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
- Maximum dose: 40 mg/day (in children less than 12 years)
PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses
IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- IV formulations should be administered in the context of palliative care.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Oral formulations should be substituted for parenteral formulations as soon as possible.
- Initial doses should be increased until an optimal level is achieved.
Uses:
- As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
- As an adjunct to post-operative analgesia
- As an analgesic in muscular discomforts
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomforts
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Management of insomnia
- Treatment of acute schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of chronic schizophrenia
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Pediatric Dose for Trigeminal Neuralgia
ORAL:
Children:
- Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
- Maximum dose: 40 mg/day (in children less than 12 years)
PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses
IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- IV formulations should be administered in the context of palliative care.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Oral formulations should be substituted for parenteral formulations as soon as possible.
- Initial doses should be increased until an optimal level is achieved.
Uses:
- As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
- As an adjunct to post-operative analgesia
- As an analgesic in muscular discomforts
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomforts
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Management of insomnia
- Treatment of acute schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of chronic schizophrenia
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Pediatric Dose for Schizophrenia
ORAL:
Children:
- Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
- Maximum dose: 40 mg/day (in children less than 12 years)
PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses
IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- IV formulations should be administered in the context of palliative care.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Oral formulations should be substituted for parenteral formulations as soon as possible.
- Initial doses should be increased until an optimal level is achieved.
Uses:
- As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
- As an adjunct to post-operative analgesia
- As an analgesic in muscular discomforts
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomforts
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Management of insomnia
- Treatment of acute schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of chronic schizophrenia
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Pediatric Dose for Nausea/Vomiting
ORAL:
Children:
- Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
- Maximum dose: 40 mg/day (in children less than 12 years)
PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses
IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- IV formulations should be administered in the context of palliative care.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Oral formulations should be substituted for parenteral formulations as soon as possible.
- Initial doses should be increased until an optimal level is achieved.
Uses:
- As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
- As an adjunct to post-operative analgesia
- As an analgesic in muscular discomforts
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomforts
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Management of insomnia
- Treatment of acute schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of chronic schizophrenia
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Pediatric Dose for Neuropathic Pain
ORAL:
Children:
- Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
- Maximum dose: 40 mg/day (in children less than 12 years)
PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses
IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- IV formulations should be administered in the context of palliative care.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Oral formulations should be substituted for parenteral formulations as soon as possible.
- Initial doses should be increased until an optimal level is achieved.
Uses:
- As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
- As an adjunct to post-operative analgesia
- As an analgesic in muscular discomforts
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomforts
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Management of insomnia
- Treatment of acute schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of chronic schizophrenia
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Usual Pediatric Dose for Breakthrough Pain
ORAL:
Children:
- Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
- Maximum dose: 40 mg/day (in children less than 12 years)
PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses
IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute
Comments:
- Use of this drug with regional or spinal anesthesia is contraindicated.
- IM injections should be administered deep into a large muscle.
- IV formulations should be administered in the context of palliative care.
- Doses given concurrently with narcotics should be appropriately reduced.
- Doses should be determined by the condition and the patient's response.
- If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
- Oral formulations should be substituted for parenteral formulations as soon as possible.
- Initial doses should be increased until an optimal level is achieved.
Uses:
- As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
- As an adjunct to post-operative analgesia
- As an analgesic in muscular discomforts
- As an analgesic in pain due to cancer
- As an analgesic in pain due to muscular discomforts
- As an analgesic in pain due to neurocostal neuralgia
- As an analgesic in pain due to trigeminal neuralgia
- As an analgesic in pain due to zona
- As an analgesic in phantom limb pains
- Management of insomnia
- Treatment of acute schizophrenia
- Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
- Treatment of chronic schizophrenia
- Treatment of manic-depressive syndromes
- Treatment of nausea and vomiting of central origin
- Treatment of psychotic disturbances
- Treatment of senile psychoses
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Contraindicated
Dose Adjustments
Patients with arteriosclerosis or cardiovascular disorders: Patients should begin with low initial treatment doses.
Large initial oral doses: Patients should be kept in bed for the first few days.
Patients taking other phenothiazines and/or central nervous system (CNS) depressants concomitantly: The usual dose of these agent(s) should be decreased by 50% if they are taken concomitantly until the dose of this drug is established.
Parenteral doses for adjunctive post-operative analgesia of 10 to 25 mg every 8 hours are equivalent to 20 to 40 mg oral doses.
Precautions
CONTRAINDICATIONS:
- Hypersensitivity to the active component or any of the ingredients
- In patients with blood dyscrasias
- Liver dysfunction
- Patients with brain damage
- Patients with central nervous system (CNS) depression or coma due to alcohol, analgesics, hypnotics, or narcotics
- Patients with circulatory collapse, severe heart disorder, and/or severe hypotension
- Pheochromocytoma
- Regional or spinal anesthesia
- Sensitivity to phenothiazines
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- Continuous subcutaneous infusions should be given with a syringe driver.
- Injections may be given via IM or IV.
Storage requirements:
- Protect from light
Reconstitution/preparation techniques:
- The manufacturer product information should be consulted.
IV compatibility:
- Compatible: Normal saline, diamorphine
General:
- Limitation of use: This drug should not be used to treat dementia-related behavioral disturbances.
- This drug does not significantly decrease respiration, and may be useful in patients with low pulmonary reserve.
Monitoring:
- CARDIOVASCULAR: ECG should be considered prior to starting treatment, before dose escalations, and in patients at maximum therapeutic doses
- HEMATOLOGIC: Complete blood count (CBC) testing prior to starting treatment, regularly during the first 2 to 3 months after initiation, and periodically thereafter
- HEPATIC: Liver function tests should be performed periodically (e.g., at least every 6 to 12 months) in patients receiving long-term treatment
- METABOLIC: Glycemic monitoring, especially during initiation; weight monitored regularly during treatment; serum electrolyte levels periodically during chronic treatment
Patient advice:
- Inform patients that this drug may cause confusion, disorientation, drowsiness, and/or excessive hypotension, and they should avoid driving or operating machinery if these side effects occur.
- Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.
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